Rhinocort
Generic Name
Budesonide
Manufacturer
AstraZeneca
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rhinocort 100 mcg nasal spray | ৳ 250.00 | N/A |
Description
Overview of the medicine
Rhinocort 100 mcg Nasal Spray contains budesonide, a corticosteroid, used to treat symptoms of seasonal and perennial allergic rhinitis. It works by reducing inflammation in the nasal passages.
Uses & Indications
Dosage
Adults
Typically 1-2 sprays (50-100 mcg) into each nostril once daily.
Elderly
No specific dosage adjustment required, use adult dose.
Renal_impairment
No dosage adjustment required.
How to Take
Shake well before use. Prime the pump before first use or after 24 hours of non-use. Spray into each nostril while blocking the other, avoiding spraying into the septum.
Mechanism of Action
Budesonide is a potent glucocorticoid with strong topical anti-inflammatory action. It reduces inflammation by inhibiting the release of inflammatory mediators and suppressing immune cell activity in the nasal mucosa.
Pharmacokinetics
Onset
Initial effects within hours, full effect within a few days.
Excretion
Mainly via urine and feces as metabolites.
Half life
Approximately 2-3 hours.
Absorption
Low systemic bioavailability (approx. 10%) due to extensive first-pass metabolism in the liver and limited absorption from the nasal mucosa.
Metabolism
Primarily hepatic via CYP3A4 to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to budesonide or any component of the formulation.
- Untreated localized infection involving the nasal mucosa.
Drug Interactions
Cimetidine
May slightly increase budesonide levels, but usually not clinically significant.
Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May significantly increase systemic exposure to budesonide, potentially leading to systemic corticosteroid effects. Concomitant use should be avoided or monitored closely.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children. Protect from light.
Overdose
Acute overdose is unlikely to cause severe effects due to low systemic absorption. Chronic overdose may lead to systemic corticosteroid effects (e.g., Cushing's syndrome, adrenal suppression). Management is supportive.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy if benefits outweigh risks. Budesonide is considered compatible with breastfeeding due to low systemic exposure.
Side Effects
Contraindications
- Hypersensitivity to budesonide or any component of the formulation.
- Untreated localized infection involving the nasal mucosa.
Drug Interactions
Cimetidine
May slightly increase budesonide levels, but usually not clinically significant.
Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May significantly increase systemic exposure to budesonide, potentially leading to systemic corticosteroid effects. Concomitant use should be avoided or monitored closely.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children. Protect from light.
Overdose
Acute overdose is unlikely to cause severe effects due to low systemic absorption. Chronic overdose may lead to systemic corticosteroid effects (e.g., Cushing's syndrome, adrenal suppression). Management is supportive.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy if benefits outweigh risks. Budesonide is considered compatible with breastfeeding due to low systemic exposure.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to product labeling for exact expiry date.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA)
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of budesonide nasal spray for allergic and non-allergic rhinitis.
Lab Monitoring
- Monitor for signs of adrenal suppression with long-term high-dose use, especially in children.
- Growth monitoring in pediatric patients with prolonged use.
Doctor Notes
- Counsel patients on proper administration technique to ensure optimal efficacy and minimize local side effects.
- Advise patients that full therapeutic effect may take several days, and adherence is crucial.
- Monitor for signs of local infection or nasal septum perforation with prolonged use, especially in patients with a history of nasal surgery or trauma.
Patient Guidelines
- Use regularly as prescribed for best results.
- Clear your nose before using the spray.
- Avoid spraying into your eyes or directly onto the nasal septum.
- Do not share your nasal spray with others to prevent infection spread.
- Consult your doctor if symptoms do not improve after a few weeks.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Rhinocort Nasal Spray is unlikely to affect the ability to drive or operate machinery.
Lifestyle Advice
- Identify and avoid known allergens (e.g., pollen, dust mites, pet dander).
- Maintain good nasal hygiene; consider saline rinses if recommended by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.