Richcal-DX
Generic Name
Calcium Carbonate 1500 mg (equivalent to Elemental Calcium 600 mg) + Vitamin D3 400 IU Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| richcal dx 600 mg tablet | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Richcal-DX 600 mg Tablet is a combination supplement containing Calcium Carbonate and Vitamin D3. It is primarily used to prevent and treat calcium and vitamin D deficiencies, promoting healthy bones, teeth, and muscle function. Calcium is a vital mineral for bone formation and maintenance, while Vitamin D3 helps the body absorb and utilize calcium effectively.
Uses & Indications
Dosage
Adults
Usually 1-2 tablets daily, or as directed by a physician. Best taken with meals for better absorption.
Elderly
No specific dose adjustment is usually required for elderly patients, but renal function should be monitored, and hypercalcemia risk considered.
Renal_impairment
Use with caution in patients with renal impairment. Serum calcium and phosphate levels should be monitored regularly. Not recommended in severe renal impairment without medical supervision.
How to Take
Administer orally, preferably with meals to enhance calcium absorption and minimize gastrointestinal upset. The tablet can be swallowed whole with water.
Mechanism of Action
Calcium Carbonate provides elemental calcium, a crucial mineral for skeletal structure, muscle contraction, nerve function, and blood coagulation. Vitamin D3 (cholecalciferol) is a fat-soluble vitamin that the body synthesizes when exposed to sunlight. It is metabolized to its active form, calcitriol, which plays a critical role in maintaining calcium and phosphate homeostasis. Calcitriol enhances intestinal absorption of calcium and phosphate, promotes bone mineralization, and influences bone remodeling processes.
Pharmacokinetics
Onset
Effects on bone health are gradual and sustained over weeks to months with regular use.
Excretion
Calcium is primarily excreted via feces, with a smaller portion excreted renally. Vitamin D3 and its metabolites are mainly excreted in the bile and feces, with some renal excretion.
Half life
The half-life of Vitamin D3 (cholecalciferol) itself is about 24 hours, but its active metabolite, calcitriol, has a half-life of 3-6 hours. Calcium has a complex kinetic profile with various compartments.
Absorption
Calcium Carbonate absorption is approximately 20-30% of the ingested dose, enhanced by Vitamin D3 and acidic environment. Vitamin D3 is well absorbed from the small intestine, primarily in the presence of bile salts.
Metabolism
Calcium is not metabolized. Vitamin D3 is hydroxylated in the liver to 25-hydroxycholecalciferol (calcifediol) and then in the kidney to 1,25-dihydroxycholecalciferol (calcitriol), the active form.
Side Effects
Contraindications
- •Hypersensitivity to Calcium Carbonate, Vitamin D3, or any component of the formulation
- •Hypercalcemia (abnormally high blood calcium levels)
- •Hypercalciuria (abnormally high urinary calcium excretion)
- •Severe renal impairment or kidney stones (nephrolithiasis)
- •Primary hyperparathyroidism
Drug Interactions
Bisphosphonates
Calcium can interfere with the absorption of bisphosphonates. Separate administration by at least 30 minutes to 2 hours.
Cardiac glycosides
Hypercalcemia can potentiate the effects of cardiac glycosides, leading to arrhythmias.
Thiazide diuretics
May reduce urinary calcium excretion, increasing the risk of hypercalcemia.
Tetracyclines & Quinolones
Calcium can chelate these antibiotics, reducing their absorption. Administer calcium at least 2-3 hours before or 4-6 hours after these antibiotics.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose primarily relate to hypercalcemia, including nausea, vomiting, constipation, abdominal pain, muscle weakness, fatigue, polydipsia, polyuria, bone pain, confusion, and in severe cases, cardiac arrhythmias and coma. Treatment involves discontinuation of the supplement, hydration, and medical management of hypercalcemia.
Pregnancy & Lactation
Calcium and Vitamin D are essential during pregnancy and lactation. This supplement can be used if medically indicated to meet increased requirements, but dosage should be determined by a healthcare professional.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture.
Availability
Pharmacies, drug stores
Approval Status
Approved
Patent Status
Generic
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