Rivadem
Generic Name
Rivastigmine
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rivadem 3 mg capsule | ৳ 40.00 | ৳ 400.00 |
Description
Overview of the medicine
Rivadem 3 mg capsule contains Rivastigmine, used for the treatment of mild to moderately severe dementia of the Alzheimer's type and mild to moderately severe dementia associated with Parkinson's disease.
Uses & Indications
Dosage
Adults
Initial dose is 1.5 mg twice daily. The dose should be gradually titrated up to the usual effective dose of 3-6 mg twice daily, with a maximum of 6 mg twice daily. Titration should occur at intervals of at least two weeks.
Elderly
No specific dose adjustment is required, but titration should be done carefully, considering the potential for increased sensitivity.
Renal_impairment
No specific dose adjustment is needed for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Take orally with food, usually in the morning and evening. Swallow the capsule whole with water. Do not chew or crush.
Mechanism of Action
Rivastigmine is a carbamate derivative that inhibits acetylcholinesterase and butyrylcholinesterase, thereby increasing the concentration of acetylcholine in the brain, which is deficient in dementia.
Pharmacokinetics
Onset
Cognitive effects may be observed within a few weeks of treatment, but full therapeutic benefits may take several months.
Excretion
Primarily renal, with over 90% of the dose excreted in urine within 24 hours. Less than 1% is excreted unchanged.
Half life
Approximately 1.5 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached in approximately 1 hour. Bioavailability is about 36%.
Metabolism
Hydrolyzed primarily by cholinesterases, predominantly via the carboxyl esterase. Minimal involvement of cytochrome P450 isoenzymes.
Side Effects
Contraindications
- Hypersensitivity to rivastigmine, other carbamate derivatives, or any component of the formulation
- Severe hepatic impairment
Drug Interactions
Beta-blockers
May increase the risk of bradycardia and syncope when co-administered.
Succinylcholine
Rivastigmine may prolong the muscle relaxation effects of succinylcholine-type muscle relaxants during anesthesia.
Anticholinergics
May antagonize the effects of anticholinergic medicinal products.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, sweating, bradycardia, hypotension, collapse, seizures, and increased muscle weakness. Treatment is supportive; atropine may be used for cholinergic crisis.
Pregnancy & Lactation
Pregnancy Category B. Should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Rivastigmine is excreted in human milk; therefore, women should not breastfeed during treatment.
Side Effects
Contraindications
- Hypersensitivity to rivastigmine, other carbamate derivatives, or any component of the formulation
- Severe hepatic impairment
Drug Interactions
Beta-blockers
May increase the risk of bradycardia and syncope when co-administered.
Succinylcholine
Rivastigmine may prolong the muscle relaxation effects of succinylcholine-type muscle relaxants during anesthesia.
Anticholinergics
May antagonize the effects of anticholinergic medicinal products.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, sweating, bradycardia, hypotension, collapse, seizures, and increased muscle weakness. Treatment is supportive; atropine may be used for cholinergic crisis.
Pregnancy & Lactation
Pregnancy Category B. Should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Rivastigmine is excreted in human milk; therefore, women should not breastfeed during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of rivastigmine in patients with mild to moderately severe Alzheimer's dementia and Parkinson's disease dementia, showing improvement in cognitive function and global clinical status.
Lab Monitoring
- No routine laboratory monitoring is typically required for rivastigmine.
- Liver function tests may be considered in patients with severe hepatic impairment.
Doctor Notes
- Monitor patients closely for gastrointestinal side effects, especially during dose titration, and manage proactively.
- Assess cardiovascular status, particularly for bradycardia or syncope, before and during treatment.
- Emphasize the importance of gradual dose titration to minimize adverse effects and improve tolerability.
- Counsel patients and caregivers on realistic expectations for treatment outcomes.
Patient Guidelines
- Take exactly as prescribed by your doctor, usually twice daily with food.
- Do not stop taking the medicine abruptly without consulting your doctor, as this may lead to worsening symptoms.
- Report any severe or persistent side effects, such as severe nausea, vomiting, or dizziness, to your healthcare provider.
- Swallow capsules whole; do not open, crush, or chew.
Missed Dose Advice
If a dose is missed, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for a missed one. If multiple doses are missed, consult your doctor before resuming treatment.
Driving Precautions
Rivastigmine may cause dizziness or somnolence, which could impair the ability to drive or operate machinery. Patients should be advised to exercise caution until they know how the medication affects them.
Lifestyle Advice
- Engage in regular mental and physical activity to support cognitive health.
- Maintain a balanced diet and ensure adequate hydration.
- Ensure sufficient sleep and manage stress effectively.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Rivadem Brand
Other medicines available under the same brand name
