Rixol
Generic Name
Ambroxol Hydrochloride
Manufacturer
Drug International Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rixol 15 mg syrup | ৳ 50.00 | N/A |
Description
Overview of the medicine
Rixol 15 mg Syrup contains Ambroxol Hydrochloride, a mucolytic agent used to thin and loosen mucus in the airways, making it easier to cough up. It is used in various respiratory conditions associated with excessive or thick mucus.
Uses & Indications
Dosage
Adults
Adults and children over 12 years: 10 ml (30 mg) 2-3 times daily.
Elderly
No specific dose adjustment required unless severe renal or hepatic impairment.
Renal_impairment
Reduce dose or increase dosing interval in severe renal impairment.
How to Take
Oral administration. Can be taken with or without food. Use measuring cup/spoon for accurate dosing.
Mechanism of Action
Ambroxol works by stimulating serous cells in the bronchial glands to produce a low-viscosity mucus, and by depolymerizing mucopolysaccharides in the mucus, thereby reducing its viscosity and facilitating mucociliary clearance.
Pharmacokinetics
Onset
Within 30 minutes
Excretion
Mainly renal, approximately 90% excreted via kidneys, mostly as metabolites.
Half life
Approximately 7-12 hours (terminal half-life)
Absorption
Rapid and complete absorption after oral administration; Tmax is 1-2.5 hours.
Metabolism
Primarily hepatic, first-pass metabolism, forming inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Ambroxol or other components
- Gastric and duodenal ulcers
Drug Interactions
Antitussives (cough suppressants)
Concomitant use with cough suppressants is not recommended as it may lead to a dangerous accumulation of bronchial secretions due to inhibition of the cough reflex.
Antibiotics (e.g., amoxicillin, cefuroxime, erythromycin, doxycycline)
Ambroxol may increase the penetration of antibiotics into bronchial secretions, potentially enhancing their efficacy.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include diarrhea, restlessness, and stomach upset. Treatment is symptomatic and supportive; gastric lavage may be considered.
Pregnancy & Lactation
Category C. Should be used with caution during pregnancy, especially in the first trimester, only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Ambroxol or other components
- Gastric and duodenal ulcers
Drug Interactions
Antitussives (cough suppressants)
Concomitant use with cough suppressants is not recommended as it may lead to a dangerous accumulation of bronchial secretions due to inhibition of the cough reflex.
Antibiotics (e.g., amoxicillin, cefuroxime, erythromycin, doxycycline)
Ambroxol may increase the penetration of antibiotics into bronchial secretions, potentially enhancing their efficacy.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include diarrhea, restlessness, and stomach upset. Treatment is symptomatic and supportive; gastric lavage may be considered.
Pregnancy & Lactation
Category C. Should be used with caution during pregnancy, especially in the first trimester, only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by drug regulatory authorities globally (e.g., DGDA)
Patent Status
Expired (generic available)
Clinical Trials
Extensive clinical trials have established the efficacy and safety of Ambroxol as a mucolytic and expectorant agent in various respiratory conditions.
Lab Monitoring
- No routine lab monitoring required for Ambroxol.
Doctor Notes
- Advise patients to stay hydrated to enhance mucolytic effect.
- Caution in patients with a history of gastric ulcers.
- Monitor for signs of severe skin reactions, although rare.
Patient Guidelines
- Do not exceed the recommended dose.
- Drink plenty of fluids to help thin mucus.
- If symptoms persist or worsen, consult a doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
Ambroxol is not known to affect the ability to drive or operate machinery. However, if you experience side effects like dizziness, avoid driving.
Lifestyle Advice
- Avoid smoking to improve respiratory health.
- Stay hydrated.
- Maintain good hygiene to prevent respiratory infections.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.