Rizelium
Generic Name
Rizatriptan
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rizelium 5 mg capsule | ৳ 3.50 | ৳ 35.00 |
Description
Overview of the medicine
Rizelium 5 mg Capsule contains Rizatriptan, which is used for the acute treatment of migraine attacks with or without aura. It helps to relieve migraine headache, pain, nausea, and sensitivity to light and sound.
Uses & Indications
Dosage
Adults
Recommended initial dose is 5 mg or 10 mg at the onset of migraine headache. If symptoms recur, a second dose may be taken after at least 2 hours. Maximum daily dose is 30 mg.
Elderly
No specific dose adjustment required for elderly patients (over 65 years) without severe renal or hepatic impairment.
Renal_impairment
Caution advised in patients with severe renal impairment. A lower initial dose (e.g., 5 mg) may be considered.
How to Take
Take one capsule orally with water, as soon as migraine symptoms begin. Do not take more than 30 mg in a 24-hour period.
Mechanism of Action
Rizatriptan is a selective serotonin 5-HT1B/1D receptor agonist. It works by constricting dilated intracranial blood vessels and inhibiting the release of pro-inflammatory neuropeptides, thereby aborting migraine attacks.
Pharmacokinetics
Onset
Usually within 30 minutes to 2 hours.
Excretion
Mainly via the kidneys (approx. 80%) and feces (approx. 17%).
Half life
Approximately 2-3 hours.
Absorption
Rapidly and well absorbed after oral administration. Peak plasma concentrations are reached in 1-1.5 hours.
Metabolism
Primarily metabolized by monoamine oxidase-A (MAO-A) to an inactive indole acetic acid metabolite.
Side Effects
Contraindications
- Ischemic heart disease or vasospastic coronary artery disease
- History of stroke or transient ischemic attack (TIA)
- Peripheral vascular disease
- Uncontrolled hypertension
- Severe hepatic impairment
- Concomitant use with MAO inhibitors or within 2 weeks of discontinuing MAO inhibitors
- Concomitant use with other 5-HT1 agonists (e.g., sumatriptan, zolmitriptan) or ergot-type medications (e.g., ergotamine, dihydroergotamine).
Drug Interactions
Propranolol
Increases rizatriptan plasma concentrations; a lower rizatriptan dose (e.g., 5 mg) is recommended if co-administered.
SSRIs/SNRIs
Potential for serotonin syndrome; caution advised.
MAO inhibitors
Increased plasma levels of rizatriptan; contraindicated.
Other 5-HT1B/1D agonists
Increased risk of vasospastic reactions; contraindicated within 24 hours.
Ergot-containing medications
Increased risk of vasospastic reactions; contraindicated.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include dizziness, somnolence, vomiting, abdominal pain, hyper-/hypotension, tachycardia, bradycardia. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Caution advised during lactation; it is unknown if rizatriptan is excreted in human milk.
Side Effects
Contraindications
- Ischemic heart disease or vasospastic coronary artery disease
- History of stroke or transient ischemic attack (TIA)
- Peripheral vascular disease
- Uncontrolled hypertension
- Severe hepatic impairment
- Concomitant use with MAO inhibitors or within 2 weeks of discontinuing MAO inhibitors
- Concomitant use with other 5-HT1 agonists (e.g., sumatriptan, zolmitriptan) or ergot-type medications (e.g., ergotamine, dihydroergotamine).
Drug Interactions
Propranolol
Increases rizatriptan plasma concentrations; a lower rizatriptan dose (e.g., 5 mg) is recommended if co-administered.
SSRIs/SNRIs
Potential for serotonin syndrome; caution advised.
MAO inhibitors
Increased plasma levels of rizatriptan; contraindicated.
Other 5-HT1B/1D agonists
Increased risk of vasospastic reactions; contraindicated within 24 hours.
Ergot-containing medications
Increased risk of vasospastic reactions; contraindicated.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include dizziness, somnolence, vomiting, abdominal pain, hyper-/hypotension, tachycardia, bradycardia. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Caution advised during lactation; it is unknown if rizatriptan is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generics available
Clinical Trials
Numerous clinical trials have established the efficacy and safety of rizatriptan in the acute treatment of migraine attacks, demonstrating superior efficacy compared to placebo and comparable to other triptans.
Lab Monitoring
- No routine lab monitoring is required. Consider ECG monitoring for patients with cardiovascular risk factors prior to initiation.
Doctor Notes
- Prioritize non-pharmacological treatments for migraine if possible.
- Counsel patients on the importance of avoiding medication overuse.
- Assess cardiovascular risk factors before prescribing.
Patient Guidelines
- Take Rizelium at the first sign of a migraine headache.
- Do not use it to prevent migraines.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Avoid driving or operating machinery until you know how this medicine affects you.
Missed Dose Advice
Rizatriptan is taken on an as-needed basis for migraine attacks, so there is no regular dosing schedule to miss. Take a dose when a migraine attack starts.
Driving Precautions
Rizatriptan may cause dizziness or drowsiness. Patients should be advised to assess their ability to drive or operate machinery before doing so.
Lifestyle Advice
- Maintain a regular sleep schedule.
- Identify and avoid migraine triggers.
- Manage stress effectively.
- Stay hydrated and eat regular meals.
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