RN-D
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rn d 500 mg tablet | ৳ 6.50 | N/A |
Description
Overview of the medicine
Paracetamol 500 mg Tablet is a widely used medication to relieve mild to moderate pain and reduce fever. It is effective for headaches, muscle aches, backaches, toothaches, menstrual pain, and cold and flu symptoms. It works by inhibiting prostaglandin synthesis in the central nervous system.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg every 4-6 hours as needed. Maximum 4000 mg (4g) in 24 hours.
Elderly
No specific dose adjustment generally required, but caution is advised in those with impaired renal or hepatic function.
Renal_impairment
Dose adjustment may be necessary. e.g., for CrCl 10-50 mL/min, administer every 6 hours; for CrCl <10 mL/min, administer every 8 hours.
How to Take
Oral administration with or without food. Can be crushed if necessary for easier swallowing.
Mechanism of Action
Paracetamol (Acetaminophen) primarily works in the central nervous system to produce analgesia and antipyresis. It is believed to inhibit prostaglandin synthesis, possibly by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, in the central nervous system. Unlike NSAIDs, it has minimal anti-inflammatory effects.
Pharmacokinetics
Onset
30-60 minutes for analgesia, 30-60 minutes for antipyresis.
Excretion
Excreted mainly by the kidneys as glucuronide and sulfate conjugates, with less than 5% excreted as unchanged drug.
Half life
Approximately 1-3 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations usually occur within 30-60 minutes after oral administration.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation. A small portion is metabolized by cytochrome P450 into a highly reactive intermediate (NAPQI) which is detoxified by glutathione.
Side Effects
Contraindications
- •Hypersensitivity to paracetamol or any component of the formulation.
- •Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Chronic heavy alcohol use may increase the risk of hepatotoxicity.
Warfarin
May increase the anticoagulant effect of warfarin, leading to increased bleeding risk, especially with chronic, high-dose use.
Isoniazid
Concomitant use may increase the risk of hepatotoxicity.
Phenytoin, Carbamazepine, Barbiturates
May increase paracetamol metabolism, potentially increasing hepatotoxicity risk.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can cause severe, sometimes fatal, liver damage. Symptoms include nausea, vomiting, abdominal pain, and loss of appetite. N-acetylcysteine (NAC) is the antidote. Seek immediate medical attention.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses. Consult a healthcare professional before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, supermarkets, online stores
Approval Status
Approved (Globally)
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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