Robic
Generic Name
robic-500-mg-tablet
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| robic 500 mg tablet | ৳ 7.02 | ৳ 42.12 |
Description
Overview of the medicine
Robic 500 mg Tablet is a fluoroquinolone antibiotic used to treat various bacterial infections, including respiratory tract, urinary tract, skin, bone, joint, and abdominal infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Typically 250 mg to 750 mg orally twice daily, depending on the infection severity and type. For Robic 500 mg, usually one tablet twice daily.
Elderly
No specific dose adjustment based solely on age, but renal function should be considered.
Renal_impairment
Dosage adjustment is necessary in patients with significant renal impairment (CrCl <30 mL/min).
How to Take
Take orally with a glass of water, with or without food. Do not take with dairy products or calcium-fortified juices. Swallow whole, do not crush or chew.
Mechanism of Action
Robic (Ciprofloxacin) inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.
Pharmacokinetics
Onset
Within 1-2 hours of administration.
Excretion
Primarily excreted renally (50-70% as unchanged drug) and to a lesser extent via the fecal route.
Half life
Approximately 3-5 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract; bioavailability is approximately 70-80%.
Metabolism
Undergoes limited hepatic metabolism (15-30%) to four metabolites with less activity.
Side Effects
Contraindications
- Hypersensitivity to Ciprofloxacin or other fluoroquinolones
- Concomitant use with tizanidine
Drug Interactions
Warfarin
May enhance anticoagulant effects, requiring INR monitoring.
Tizanidine
Concomitant use is contraindicated due to increased tizanidine plasma concentrations and adverse effects.
Theophylline
Increases plasma concentrations of Theophylline, leading to increased risk of toxicity.
Antacids (containing magnesium or aluminum)
Reduces absorption of Ciprofloxacin; take Ciprofloxacin 2 hours before or 6 hours after antacids.
Storage
Store in a cool, dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic treatment and supportive measures should be initiated. Gastric lavage and activated charcoal may be considered. Maintain adequate hydration.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted in human milk; avoid during breastfeeding or use with caution.
Side Effects
Contraindications
- Hypersensitivity to Ciprofloxacin or other fluoroquinolones
- Concomitant use with tizanidine
Drug Interactions
Warfarin
May enhance anticoagulant effects, requiring INR monitoring.
Tizanidine
Concomitant use is contraindicated due to increased tizanidine plasma concentrations and adverse effects.
Theophylline
Increases plasma concentrations of Theophylline, leading to increased risk of toxicity.
Antacids (containing magnesium or aluminum)
Reduces absorption of Ciprofloxacin; take Ciprofloxacin 2 hours before or 6 hours after antacids.
Storage
Store in a cool, dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic treatment and supportive measures should be initiated. Gastric lavage and activated charcoal may be considered. Maintain adequate hydration.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted in human milk; avoid during breastfeeding or use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by Regulatory Authority
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Ciprofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety in treating various bacterial infections. Ongoing research continues to explore its applications and resistance patterns.
Lab Monitoring
- Renal function tests (e.g., creatinine, BUN) in patients with kidney impairment
- Liver function tests (e.g., ALT, AST) if liver dysfunction is suspected
- Complete Blood Count (CBC) during prolonged therapy
Doctor Notes
- Assess renal function before initiating and during therapy, especially in elderly patients or those with pre-existing renal impairment.
- Counsel patients on the importance of completing the full course and promptly reporting any adverse effects, particularly musculoskeletal pain or neurological symptoms.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve, to prevent antibiotic resistance.
- Stay well-hydrated by drinking plenty of fluids.
- Avoid direct sunlight and use protective clothing/sunscreen due to potential photosensitivity.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or lightheadedness, which can impair ability to drive or operate machinery. Exercise caution.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Report any unusual pain, especially in joints or tendons, immediately to your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.