Medicine Information

Rolac

Name: Rolac
Brand: Rolac
Rating: 4.5 (117 reviews)

Tablet, Injection, Ophthalmic Solution10 mg, 30 mg/mLNon-Steroidal Anti-Inflammatory Drugs (NSAIDs)ATC: M01AB15

Generic Name

Ketorolac

Manufacturer

ACI Limited

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
rolac 10 mg tablet	৳ 12.00	৳ 168.00
rolac 10 mg injection	৳ 32.13	N/A
rolac 30 mg injection	৳ 55.21	N/A
rolac 60 mg injection	৳ 95.36	N/A

Description

Overview of the medicine

Rolac (Ketorolac) is a potent non-steroidal anti-inflammatory drug (NSAID) used for the short-term management of moderate to severe acute pain. It is often used post-operatively or for other acute pain conditions where opioid analgesics may be considered.

Uses & Indications

Short-term management of moderate to severe acute pain (e.g., postoperative pain).

Pain management after dental procedures.

Management of acute musculoskeletal pain.

Dosage

Adults

Oral: 10 mg every 4-6 hours as needed, not to exceed 40 mg/day. Total treatment duration should not exceed 5 days. IM/IV: Single dose of 30 mg or 30 mg every 6 hours, not to exceed 120 mg/day. Total treatment duration should not exceed 5 days.

Elderly

Lower doses may be required. For IM/IV, max 60 mg/day. Close monitoring for adverse effects is recommended.

Renal_impairment

Significant dose reduction or avoidance is necessary depending on the degree of renal impairment. Contraindicated in severe renal impairment.

How to Take

Oral tablets should be taken with food or milk to minimize gastrointestinal upset. Injections can be given intramuscularly (IM) or intravenously (IV).

Mechanism of Action

Ketorolac inhibits prostaglandin synthesis by non-selectively blocking the cyclooxygenase (COX-1 and COX-2) enzymes. This reduction in prostaglandins leads to its analgesic, anti-inflammatory, and antipyretic effects.

Pharmacokinetics

Onset

Oral: 30-60 minutes; Intramuscular/Intravenous: within 10 minutes.

Excretion

Mainly via urine (about 92%), with a small portion excreted in feces.

Half life

Approximately 5-6 hours.

Absorption

Rapidly and completely absorbed after oral administration. Peak plasma concentrations are reached within 30-60 minutes.

Metabolism

Primarily hepatic, mainly through glucuronidation and hydroxylation.

Side Effects

Contraindications

Active peptic ulcer, recent gastrointestinal bleeding or perforation, history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Severe renal impairment (creatinine clearance <30 mL/min).
Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Advanced liver disease.
Hypersensitivity to Ketorolac or any component of the formulation.
Children below 17 years for parenteral use.

Drug Interactions

Lithium

Increased plasma lithium concentrations (reduced renal clearance of lithium).

Methotrexate

Increased methotrexate toxicity (reduced renal clearance).

Corticosteroids

Increased risk of GI ulceration and bleeding.

ACE inhibitors, ARBs, Diuretics

May reduce antihypertensive and diuretic effects; increased risk of renal impairment.

Anticoagulants (e.g., Warfarin, Heparin)

Increased risk of bleeding.

Antiplatelet agents (e.g., Aspirin, Clopidogrel)

Increased risk of GI bleeding.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric pain, GI bleeding, lethargy, drowsiness, and acute renal failure. Management involves supportive and symptomatic treatment. Gastric lavage and activated charcoal may be considered within the first hour of ingestion. Monitor renal and liver function.

Pregnancy & Lactation

Pregnancy: Category C in early pregnancy, Category D in third trimester. Avoid in the third trimester due to potential for premature closure of the fetal ductus arteriosus. Lactation: Small amounts are excreted in breast milk. Use with caution or avoid during breastfeeding, weighing potential risks against benefits.

Side Effects

Contraindications

Active peptic ulcer, recent gastrointestinal bleeding or perforation, history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Severe renal impairment (creatinine clearance <30 mL/min).
Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Advanced liver disease.
Hypersensitivity to Ketorolac or any component of the formulation.
Children below 17 years for parenteral use.

Drug Interactions

Lithium

Increased plasma lithium concentrations (reduced renal clearance of lithium).

Methotrexate

Increased methotrexate toxicity (reduced renal clearance).

Corticosteroids

Increased risk of GI ulceration and bleeding.

ACE inhibitors, ARBs, Diuretics

May reduce antihypertensive and diuretic effects; increased risk of renal impairment.

Anticoagulants (e.g., Warfarin, Heparin)

Increased risk of bleeding.

Antiplatelet agents (e.g., Aspirin, Clopidogrel)

Increased risk of GI bleeding.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 mg tablets: 10 tablets per blister, 3 blisters per box (30 tablets).30 mg/mL injection: 1 ampoule per box, 5 ampoules per box.

Shelf Life

Typically 24-36 months from the date of manufacture, specific details on packaging.

Availability

Available in pharmacies and hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Ketorolac has undergone extensive clinical trials demonstrating its efficacy in acute pain management, often compared to opioids. Trials consistently show its potent analgesic effect but also highlight its dose- and duration-dependent risks, particularly GI and renal complications.

Lab Monitoring

Renal function (serum creatinine, BUN) before and during treatment, especially in patients at risk of renal impairment.
Liver function tests (ALT, AST) periodically, particularly with long-term use.
Complete blood count (CBC) if used for more than a few days, especially if there's a risk of bleeding.

Doctor Notes

Emphasize the strict 5-day maximum duration for all routes of administration to minimize GI and CV risks.
Consider patient's cardiovascular and renal history before prescribing.
Co-administration with other NSAIDs, antiplatelets, or anticoagulants should be carefully evaluated due to increased bleeding risk.

Patient Guidelines

Take exactly as prescribed and do not exceed the recommended dose or duration of treatment (maximum 5 days).
Report any signs of gastrointestinal bleeding (e.g., black, tarry stools, vomiting blood) or allergic reactions immediately.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Ketorolac may cause dizziness, drowsiness, or visual disturbances. Patients should exercise caution when driving or operating machinery until they know how the medication affects them.

Lifestyle Advice

Avoid alcohol consumption while taking Ketorolac, as it may increase the risk of gastrointestinal bleeding. Discuss any history of stomach ulcers, heart disease, or kidney problems with your doctor before starting treatment.
Maintain adequate hydration.