Rolac-MDT
Generic Name
Ketorolac Tromethamine
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rolac mdt 10 mg tablet | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Rolac-MDT 10 mg Tablet contains Ketorolac Tromethamine, a non-steroidal anti-inflammatory drug (NSAID) used for the short-term management of moderately severe acute pain that requires analgesia at the opioid level. The mouth-dissolving tablet formulation provides rapid onset of action and convenience of administration without water.
Uses & Indications
Dosage
Adults
10 mg every 4-6 hours as needed, maximum 40 mg/day for not more than 5 days.
Elderly
Lower doses recommended, e.g., 10 mg every 6-8 hours, maximum 30 mg/day, due to increased risk of side effects.
Renal_impairment
Dose reduction necessary; e.g., 10 mg every 6-8 hours, max 30 mg/day for mild to moderate impairment. Contraindicated in severe renal impairment.
How to Take
Place the mouth-dissolving tablet on the tongue. It will rapidly disintegrate in the saliva. Swallow the dissolved medicine with saliva. No water is required for administration.
Mechanism of Action
Ketorolac acts by inhibiting the synthesis of prostaglandins through the non-selective inhibition of cyclooxygenase (COX-1 and COX-2) enzymes. Prostaglandins are mediators of pain, inflammation, and fever, thus reducing these symptoms.
Pharmacokinetics
Onset
Approximately 30 minutes.
Excretion
Primarily renal (approx. 90%), with some fecal excretion.
Half life
4-6 hours.
Absorption
Rapidly and completely absorbed after oral administration. Peak plasma concentrations reached within 30-60 minutes.
Metabolism
Primarily hepatic (glucuronidation, hydroxylation).
Side Effects
Contraindications
- •Hypersensitivity to Ketorolac or other NSAIDs.
- •Active peptic ulcer, gastrointestinal bleeding or perforation.
- •Advanced renal impairment.
- •Patients at risk for bleeding (e.g., coagulation disorders).
- •Third trimester of pregnancy.
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, and gastrointestinal bleeding. Management involves symptomatic and supportive treatment. Gastric lavage or activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C (D in third trimester or near delivery). Avoid use in the third trimester of pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use with caution in early pregnancy if benefits outweigh risks. Not recommended during breastfeeding as Ketorolac is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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