Romfen-S
Generic Name
Bromfenac Sodium Ophthalmic Solution
Manufacturer
Hypothetical Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| romfen s 007 eye drop | ৳ 90.00 | N/A |
Description
Overview of the medicine
Romfen-S 007 Eye Drop contains Bromfenac Sodium, a non-steroidal anti-inflammatory drug (NSAID) used to treat inflammation and pain associated with cataract surgery.
Uses & Indications
Dosage
Adults
One drop to the affected eye(s) twice daily starting 24 hours after surgery and continuing for 2 weeks.
Elderly
No dosage adjustment necessary.
Renal_impairment
No specific dosage adjustment guidance, as systemic absorption is minimal.
How to Take
For ophthalmic use only. Tilt head back, pull down lower eyelid to create a pouch, and instill the drop. Close eye gently. Avoid touching the dropper tip to any surface.
Mechanism of Action
Bromfenac is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the activity of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. This inhibition prevents the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever, thereby reducing ocular inflammation and pain.
Pharmacokinetics
Onset
Within 1-2 hours for pain relief.
Excretion
Excreted primarily via the urine as metabolites.
Half life
Approximately 1.5 hours in aqueous humor.
Absorption
Well absorbed into ocular tissues after topical administration. Systemic absorption is minimal.
Metabolism
Primarily metabolized by cytochrome P450 enzymes (mainly CYP2C9) in the liver and ocular tissues.
Side Effects
Contraindications
- Hypersensitivity to Bromfenac or any components of the formulation.
- Patients with a history of allergic reactions to NSAIDs (e.g., aspirin-induced asthma).
Drug Interactions
Topical Corticosteroids
May increase the risk of corneal healing complications.
Anticoagulants (e.g., Warfarin)
Systemic absorption is minimal, but theoretical risk of increased bleeding tendency with other drugs affecting coagulation.
Storage
Store at room temperature (15°C to 30°C). Do not refrigerate or freeze. Keep out of reach of children.
Overdose
Overdose from ophthalmic administration is unlikely due to the small amount of drug and minimal systemic absorption. If accidentally ingested, symptomatic and supportive measures should be taken.
Pregnancy & Lactation
Use during pregnancy should be avoided in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during earlier pregnancy and lactation; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Bromfenac or any components of the formulation.
- Patients with a history of allergic reactions to NSAIDs (e.g., aspirin-induced asthma).
Drug Interactions
Topical Corticosteroids
May increase the risk of corneal healing complications.
Anticoagulants (e.g., Warfarin)
Systemic absorption is minimal, but theoretical risk of increased bleeding tendency with other drugs affecting coagulation.
Storage
Store at room temperature (15°C to 30°C). Do not refrigerate or freeze. Keep out of reach of children.
Overdose
Overdose from ophthalmic administration is unlikely due to the small amount of drug and minimal systemic absorption. If accidentally ingested, symptomatic and supportive measures should be taken.
Pregnancy & Lactation
Use during pregnancy should be avoided in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during earlier pregnancy and lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months unopened; discard 28 days after opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generics available, patent expired
Clinical Trials
Clinical trials demonstrated significant reduction in ocular pain and inflammation following cataract surgery compared to placebo.
Lab Monitoring
- No specific lab monitoring is required for ophthalmic use due to minimal systemic absorption.
Doctor Notes
- Advise patients to report any signs of corneal toxicity immediately.
- Emphasize proper administration technique to minimize contamination.
- Caution against use in patients with compromised corneas or history of herpetic keratitis.
Patient Guidelines
- Wash hands thoroughly before use.
- Do not wear contact lenses while using this medication unless directed by your doctor.
- Wait at least 5 minutes before using other eye drops.
- Do not touch the dropper tip to your eye or any other surface.
Missed Dose Advice
If a dose is missed, apply it as soon as possible. If it is almost time for the next dose, skip the missed dose and return to the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision; avoid driving or operating machinery until vision is clear.
Lifestyle Advice
- Avoid activities that may cause eye strain immediately after application.
- Protect eyes from bright light if experiencing photophobia.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.