Ronac Plus
Generic Name
Diclofenac Sodium + Paracetamol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ronac plus 75 mg injection | ৳ 15.04 | N/A |
Description
Overview of the medicine
Ronac Plus is a combination medicine containing Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID), and Paracetamol (Acetaminophen), an analgesic and antipyretic. It is used to relieve pain and inflammation associated with various conditions.
Uses & Indications
Dosage
Adults
One tablet 2-3 times daily, preferably after food.
Elderly
Lower doses may be required; monitor for adverse effects.
Renal_impairment
Caution advised; dose adjustment may be necessary in severe impairment.
How to Take
Oral administration. Take with a glass of water, preferably after meals to minimize gastrointestinal upset.
Mechanism of Action
Diclofenac inhibits prostaglandin synthesis by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, reducing inflammation, pain, and fever. Paracetamol primarily inhibits prostaglandin synthesis in the central nervous system, producing analgesic and antipyretic effects.
Pharmacokinetics
Onset
Pain relief usually within 30-60 minutes.
Excretion
Mainly via urine (Diclofenac as metabolites, Paracetamol as conjugates and metabolites).
Half life
Diclofenac: 1-2 hours; Paracetamol: 1.5-3 hours.
Absorption
Both Diclofenac and Paracetamol are well absorbed orally. Diclofenac peak plasma levels are reached in 2-3 hours; Paracetamol in 30-60 minutes.
Metabolism
Both undergo hepatic metabolism (Diclofenac via CYP2C9, UGT; Paracetamol via glucuronidation and sulfation).
Side Effects
Contraindications
- Hypersensitivity to Diclofenac, Paracetamol, or other NSAIDs
- Active gastrointestinal ulceration, bleeding, or perforation
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Alcohol
Increased risk of hepatotoxicity with paracetamol.
Warfarin/Anticoagulants
Increased risk of bleeding.
Diuretics/ACE inhibitors
Reduced antihypertensive effect; increased risk of renal impairment.
Lithium/Digoxin/Methotrexate
Increased plasma levels.
Other NSAIDs/Corticosteroids
Increased risk of GI adverse effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, drowsiness, and GI bleeding. Paracetamol overdose can lead to severe hepatotoxicity. Diclofenac overdose can cause acute renal failure. Treatment is supportive; N-acetylcysteine for paracetamol overdose. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of ductus arteriosus. Use with caution in first and second trimesters only if potential benefit outweighs risk. Diclofenac and Paracetamol pass into breast milk; generally considered safe in usual doses during lactation, but caution is advised.
Side Effects
Contraindications
- Hypersensitivity to Diclofenac, Paracetamol, or other NSAIDs
- Active gastrointestinal ulceration, bleeding, or perforation
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Alcohol
Increased risk of hepatotoxicity with paracetamol.
Warfarin/Anticoagulants
Increased risk of bleeding.
Diuretics/ACE inhibitors
Reduced antihypertensive effect; increased risk of renal impairment.
Lithium/Digoxin/Methotrexate
Increased plasma levels.
Other NSAIDs/Corticosteroids
Increased risk of GI adverse effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, drowsiness, and GI bleeding. Paracetamol overdose can lead to severe hepatotoxicity. Diclofenac overdose can cause acute renal failure. Treatment is supportive; N-acetylcysteine for paracetamol overdose. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of ductus arteriosus. Use with caution in first and second trimesters only if potential benefit outweighs risk. Diclofenac and Paracetamol pass into breast milk; generally considered safe in usual doses during lactation, but caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Combination widely studied; specific trials for Ronac Plus brand may be available from the manufacturer.
Lab Monitoring
- Liver function tests (especially with prolonged use)
- Kidney function tests
- Blood counts (for signs of GI bleeding)
Doctor Notes
- Caution in patients with a history of GI disorders, hypertension, or heart failure.
- Regular monitoring of renal and hepatic function is advised for prolonged therapy.
Patient Guidelines
- Take as directed by your doctor
- Do not exceed the recommended dose
- Take with food or milk to prevent stomach upset
- Inform your doctor about all other medications you are taking
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; exercise caution when driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption while taking this medication
- Stay hydrated
- Avoid prolonged sun exposure if photosensitivity occurs
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.