Ropenem
Generic Name
Ropenem 1 gm injection
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ropenem 1 gm injection | ৳ 1,150.00 | N/A |
Description
Overview of the medicine
Ropenem is a broad-spectrum carbapenem antibiotic used to treat a wide range of severe bacterial infections, particularly those caused by multi-drug resistant bacteria. It is administered intravenously.
Uses & Indications
Dosage
Adults
1 gm administered intravenously every 8 hours. Dosage may vary based on infection severity and type.
Elderly
No specific dose adjustment is generally required for elderly patients with normal renal function. Renal function should be monitored.
Renal_impairment
Dose adjustment required based on creatinine clearance. For CrCl 26-50 mL/min: 1 gm every 12 hours. For CrCl 10-25 mL/min: 500 mg every 12 hours. For CrCl <10 mL/min: 500 mg every 24 hours.
How to Take
Ropenem 1 gm injection is for intravenous use only. It should be reconstituted with an appropriate diluent (e.g., Water for Injection, 0.9% Sodium Chloride) and administered as an intravenous infusion over 15-30 minutes, or as a bolus over 3-5 minutes for certain infections.
Mechanism of Action
Ropenem exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) inside the bacterial cell, which interferes with the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Rapid onset of action, typically within minutes of IV infusion.
Excretion
Mainly excreted unchanged in the urine, approximately 70% within 12 hours.
Half life
Approximately 1 hour (varies with renal function).
Absorption
Rapid and complete absorption after intravenous administration.
Metabolism
Primarily metabolized in the kidney by dehydropeptidase-I, but Ropenem is typically stable to this enzyme.
Side Effects
Contraindications
- Known hypersensitivity to ropenem or other carbapenem antibiotics
- Severe hypersensitivity (e.g., anaphylactic reaction, severe skin reaction) to any other beta-lactam antibacterial agent
Drug Interactions
Probenecid
Increases Ropenem plasma concentrations and prolongs its half-life by inhibiting renal excretion. Not usually recommended.
Valproic acid
Concurrent use may decrease valproic acid levels, leading to loss of seizure control. Co-administration is generally not recommended.
Oral anticoagulants
May enhance the anticoagulant effect of warfarin and other oral anticoagulants.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, discontinue Ropenem and institute general supportive treatment. Ropenem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed. Ropenem is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date (unreconstituted). Reconstituted solution should be used immediately.
Availability
Hospitals and pharmacies
Approval Status
Approved by regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
As a hypothetical carbapenem, Ropenem would undergo rigorous clinical trials (Phase I, II, III) to establish its safety and efficacy for various indications, comparing it against existing standard treatments.
Lab Monitoring
- Renal function (creatinine, BUN)
- Liver function tests (ALT, AST)
- Complete blood count (CBC) during prolonged therapy
Doctor Notes
- Empiric therapy with Ropenem should be guided by local epidemiological data and susceptibility patterns.
- Dosage adjustment is crucial in patients with renal impairment to avoid adverse effects, especially CNS toxicity.
- Monitor for signs of superinfection and C. difficile infection during and after treatment.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Report any severe side effects, especially seizures, severe diarrhea, or allergic reactions.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Ropenem may cause dizziness or seizures in some patients, which could impair the ability to drive or operate machinery. Patients should be advised to exercise caution.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Stay hydrated during treatment.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.