Ropenia
Generic Name
Recombinant Human Erythropoietin-alpha
Manufacturer
Global BioPharma
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ropenia 300 mcg injection | ৳ 3,400.00 | N/A |
Description
Overview of the medicine
Ropenia 300 mcg Injection is a recombinant human erythropoietin-alpha used to treat anemia associated with chronic kidney disease and chemotherapy in certain cancer patients. It works by stimulating the bone marrow to produce more red blood cells.
Uses & Indications
Dosage
Adults
Initial dose typically 50-100 units/kg intravenously (IV) or subcutaneously (SC) three times per week, or 10,000 units once weekly for chemotherapy-induced anemia. Dosage adjusted based on hemoglobin response.
Elderly
No specific dose adjustment required, but monitor closely due to potential comorbidities.
Renal_impairment
Initial dose for CKD patients: 50-100 units/kg IV or SC three times per week, target hemoglobin 10-12 g/dL.
How to Take
Ropenia is administered via subcutaneous (SC) or intravenous (IV) injection. For SC administration, ensure proper technique for self-injection if performed by the patient. For IV administration, it should be given slowly over 1 to 5 minutes.
Mechanism of Action
Erythropoietin-alpha stimulates erythropoiesis by interacting with the erythropoietin receptor on progenitor cells in the bone marrow, promoting their proliferation and differentiation into mature red blood cells.
Pharmacokinetics
Onset
Hemoglobin response usually begins within 2-6 weeks.
Excretion
A small fraction is excreted renally; metabolic clearance is the primary route.
Half life
The elimination half-life is approximately 4-13 hours following intravenous (IV) administration and 12-28 hours following subcutaneous (SC) administration.
Absorption
Subcutaneous (SC) administration results in slow and sustained absorption, reaching peak serum concentrations after 12-18 hours. Bioavailability is approximately 20-30%.
Metabolism
Primarily metabolized by non-renal mechanisms, likely hepatic uptake and degradation.
Side Effects
Contraindications
- Uncontrolled hypertension.
- Known hypersensitivity to human albumin or products derived from mammalian cells.
- Patients with pure red cell aplasia (PRCA) unrelated to erythropoietin therapy.
Drug Interactions
Iron Supplements
Requires adequate iron stores for optimal response. Iron supplementation is often necessary.
Other Erythropoiesis-Stimulating Agents
Do not co-administer with other ESAs.
Storage
Store in a refrigerator (2°C - 8°C). Do not freeze. Protect from light. Do not shake.
Overdose
Overdose can lead to polycythemia (abnormally high red blood cell count), which may require phlebotomy. Symptoms may include elevated blood pressure and an increased risk of thromboembolic events. Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is unknown whether erythropoietin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored correctly.
Availability
Available in hospitals, clinics, and pharmacies
Approval Status
Approved by regulatory authorities
Patent Status
Generic available for the class
WHO Essential Medicine
YesClinical Trials
Ongoing clinical trials continue to investigate the optimal use of ESAs in various anemic conditions and to assess long-term safety profiles.
Lab Monitoring
- Hemoglobin and hematocrit levels (monitor twice weekly until stable, then weekly/bi-weekly)
- Iron status (ferritin, transferrin saturation) prior to and during treatment
- Blood pressure (monitor regularly)
- Electrolytes, particularly potassium
Doctor Notes
- Ensure adequate iron status before and during Ropenia treatment.
- Monitor hemoglobin levels closely and adjust dose to avoid levels above 11 g/dL.
- Educate patients on symptoms of thromboembolic events and strict adherence to blood pressure monitoring.
Patient Guidelines
- Do not shake the vial/syringe.
- Store in the refrigerator (2-8°C) and protect from light.
- Do not freeze.
- Report any signs of blood clots (e.g., chest pain, swelling in limbs) immediately.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Ropenia is unlikely to affect the ability to drive or operate machinery. However, if side effects like seizures or severe headache occur, avoid driving.
Lifestyle Advice
- Maintain a balanced diet rich in iron.
- Stay well-hydrated.
- Regularly monitor blood pressure at home.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.