Rosicard
Generic Name
Rosuvastatin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rosicard 5 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Rosicard 5 mg Tablet contains Rosuvastatin, a statin medication used to lower high cholesterol and triglycerides in the blood, thereby reducing the risk of heart disease and stroke.
Uses & Indications
Dosage
Adults
Initial dose 5 mg or 10 mg once daily. For patients requiring less aggressive LDL-C reduction, 5 mg once daily may be considered. Dose adjustment should be made at 2-4 week intervals. Maximum dose is 40 mg once daily.
Elderly
For patients >70 years, a starting dose of 5 mg is recommended.
Renal_impairment
In severe renal impairment (CrCl <30 mL/min) not on hemodialysis, the starting dose should be 5 mg and should not exceed 10 mg once daily. No dosage adjustment for mild to moderate renal impairment.
How to Take
Take orally once daily, with or without food. Can be taken at any time of day.
Mechanism of Action
Rosuvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis. It reduces LDL-C, Total-C, ApoB, and TG, and increases HDL-C.
Pharmacokinetics
Onset
Lipid-lowering effect is evident within 1 week of therapy, with 90% of maximum response achieved by 2 weeks.
Excretion
Excreted primarily in feces (approximately 90%), with minimal renal excretion.
Half life
Approximately 19 hours.
Absorption
Approximately 20% absolute bioavailability. Peak plasma concentrations are reached in 3 to 5 hours.
Metabolism
Limited metabolism, primarily by CYP2C9 (approximately 10%).
Side Effects
Contraindications
- Hypersensitivity to rosuvastatin or any component of the formulation
- Active liver disease, including unexplained persistent elevations of serum transaminases
- Severe renal impairment (creatinine clearance <30 mL/min)
- Myopathy
- Concomitant cyclosporine use
- Pregnancy and lactation
Drug Interactions
Ezetimibe
Increased risk of muscle problems.
Gemfibrozil
Increases rosuvastatin exposure; avoid co-administration if possible.
Cyclosporine
Significant increase in rosuvastatin exposure; co-administration contraindicated.
Erythromycin
Decreased rosuvastatin exposure.
Warfarin/Coumarin anticoagulants
Increased INR; monitor INR closely.
Protease inhibitors (e.g., Lopinavir/Ritonavir)
Increased rosuvastatin exposure; dose adjustment may be necessary.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for rosuvastatin overdose. In the event of an overdose, symptomatic and supportive measures should be instituted. Hemodialysis is unlikely to be of benefit.
Pregnancy & Lactation
Rosuvastatin is contraindicated during pregnancy (Pregnancy Category X) and lactation. Women of childbearing potential should use adequate contraception.
Side Effects
Contraindications
- Hypersensitivity to rosuvastatin or any component of the formulation
- Active liver disease, including unexplained persistent elevations of serum transaminases
- Severe renal impairment (creatinine clearance <30 mL/min)
- Myopathy
- Concomitant cyclosporine use
- Pregnancy and lactation
Drug Interactions
Ezetimibe
Increased risk of muscle problems.
Gemfibrozil
Increases rosuvastatin exposure; avoid co-administration if possible.
Cyclosporine
Significant increase in rosuvastatin exposure; co-administration contraindicated.
Erythromycin
Decreased rosuvastatin exposure.
Warfarin/Coumarin anticoagulants
Increased INR; monitor INR closely.
Protease inhibitors (e.g., Lopinavir/Ritonavir)
Increased rosuvastatin exposure; dose adjustment may be necessary.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for rosuvastatin overdose. In the event of an overdose, symptomatic and supportive measures should be instituted. Hemodialysis is unlikely to be of benefit.
Pregnancy & Lactation
Rosuvastatin is contraindicated during pregnancy (Pregnancy Category X) and lactation. Women of childbearing potential should use adequate contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic versions available
Clinical Trials
Rosuvastatin has been extensively studied in various clinical trials, including the JUPITER trial, demonstrating its efficacy in lowering LDL-C and reducing cardiovascular events.
Lab Monitoring
- Liver function tests (LFTs) should be performed before initiation of therapy and periodically thereafter, or as clinically indicated.
- Creatine kinase (CK) levels should be measured if muscle symptoms occur.
Doctor Notes
- Monitor LFTs before and periodically during therapy. Discontinue if transaminase levels exceed 3 times the upper limit of normal.
- Consider a lower starting dose (e.g., 5 mg) for Asian patients or those with predisposing factors for myopathy.
- Advise patients to report any unexplained muscle pain or weakness promptly.
Patient Guidelines
- Take Rosicard 5 mg Tablet exactly as prescribed by your doctor, usually once daily.
- Inform your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or dark urine.
- Do not stop taking the medicine without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.
Driving Precautions
Rosicard is unlikely to affect the ability to drive or operate machinery. However, some patients may experience dizziness, so caution is advised.
Lifestyle Advice
- Maintain a healthy diet low in saturated fat and cholesterol.
- Engage in regular physical activity.
- Avoid smoking and limit alcohol intake.
- Achieve and maintain a healthy weight.
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