Rosu
Generic Name
Rosuvastatin
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rosu 10 mg tablet | ৳ 24.00 | ৳ 240.00 |
Description
Overview of the medicine
Rosuvastatin is a statin medication used to lower high cholesterol and triglyceride levels, reducing the risk of cardiovascular diseases such as heart attack and stroke. It works by reducing the amount of cholesterol made by the liver.
Uses & Indications
Dosage
Adults
Initial dose 5-10 mg once daily. For 10 mg tablet, commonly 10 mg once daily. Max 40 mg once daily.
Elderly
No general dosage adjustment required, but an initial dose of 5 mg is recommended for patients >70 years.
Renal_impairment
Mild to moderate impairment: No dosage adjustment needed. Severe impairment (CrCl <30 mL/min): Initial dose 5 mg once daily, max 10 mg once daily.
How to Take
Take orally, once daily, with or without food. It is recommended to take the tablet at the same time each day for better adherence.
Mechanism of Action
Rosuvastatin selectively inhibits HMG-CoA reductase, an enzyme responsible for catalyzing the rate-limiting step in cholesterol biosynthesis. This inhibition decreases hepatic cholesterol synthesis and increases the number of LDL receptors on the surface of liver cells, enhancing the uptake and catabolism of LDL (low-density lipoprotein) cholesterol.
Pharmacokinetics
Onset
Lipid-modifying effects are evident within 1 week of starting therapy, with maximal effect generally observed by 2 to 4 weeks.
Excretion
Approximately 90% of a rosuvastatin dose is excreted unchanged in the feces, with about 5% excreted in the urine.
Half life
The elimination half-life of rosuvastatin is approximately 19 hours.
Absorption
Peak plasma concentrations are achieved approximately 3 to 5 hours after oral administration. Absolute bioavailability is approximately 20%.
Metabolism
Rosuvastatin undergoes limited metabolism, primarily by cytochrome P450 (CYP2C9). N-desmethyl rosuvastatin is the major metabolite.
Side Effects
Contraindications
- •Active liver disease, including unexplained persistent elevations of serum transaminases.
- •Severe renal impairment (CrCl <30 mL/min).
- •Myopathy or predisposition to myopathy.
- •Concurrent administration of cyclosporine.
- •Pregnancy and lactation.
- •Hypersensitivity to rosuvastatin or any component of the formulation.
Drug Interactions
Cyclosporine
Concurrent use increases rosuvastatin exposure significantly and is contraindicated.
Erythromycin
Decreases rosuvastatin exposure.
Oral contraceptives
May increase AUC of ethinyl estradiol and norgestrel; consider this when selecting contraceptive method.
Gemfibrozil or other fibrates
Increases rosuvastatin exposure and risk of myopathy; concurrent use should be avoided or dose limited.
Warfarin and other Vitamin K antagonists
May increase INR (International Normalized Ratio); monitor INR closely.
Antacids (aluminum & magnesium hydroxide)
Decreases rosuvastatin plasma concentration; take antacids 2 hours after rosuvastatin.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for rosuvastatin overdose. In case of an overdose, treatment should be symptomatic and supportive. Liver function and CK levels should be monitored. Hemodialysis is unlikely to be of benefit.
Pregnancy & Lactation
Rosuvastatin is contraindicated during pregnancy due to the potential for fetal harm. Women of childbearing potential should use effective contraception. It is also contraindicated during lactation as it may pass into breast milk and potentially harm the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA/DGDA)
Patent Status
Generically available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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