Rosugen
Generic Name
Rosuvastatin Calcium
Manufacturer
Healthgen Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rosugen 10 mg tablet | ৳ 27.00 | ৳ 270.00 |
Description
Overview of the medicine
Rosugen 10 mg Tablet is used to lower high cholesterol levels and reduce the risk of heart disease and stroke.
Uses & Indications
Dosage
Adults
Initial dose 5-10 mg orally once daily. Maximum dose 40 mg once daily.
Elderly
Starting dose of 5 mg is recommended for patients ≥70 years, but generally same as adults, with caution for higher doses.
Renal_impairment
For severe renal impairment (CrCl <30 mL/min), initial dose of 5 mg once daily, not to exceed 10 mg once daily.
How to Take
Take orally once daily, with or without food, at any time of day, but preferably at the same time each day.
Mechanism of Action
Rosuvastatin inhibits HMG-CoA reductase, an enzyme responsible for cholesterol synthesis in the liver, thereby reducing LDL ('bad') cholesterol and increasing HDL ('good') cholesterol.
Pharmacokinetics
Onset
Lipid-lowering effects are evident within 1 week, with maximal effect generally achieved by 2-4 weeks of therapy.
Excretion
Approximately 90% of rosuvastatin is excreted unchanged in the feces, and a small portion in the urine.
Half life
The elimination half-life of rosuvastatin is approximately 19 hours.
Absorption
Peak plasma concentrations are achieved in approximately 3-5 hours. Absolute bioavailability is about 20%.
Metabolism
Rosuvastatin undergoes limited metabolism, primarily by cytochrome P450 isoenzyme CYP2C9.
Side Effects
Contraindications
- Active liver disease, including unexplained persistent elevations of serum transaminases
- Pregnancy
- Lactation
- Hypersensitivity to rosuvastatin or any component of the formulation
- Severe renal impairment (CrCl <30 mL/min)
Drug Interactions
Warfarin
May enhance the anticoagulant effect. INR monitoring required.
Gemfibrozil
May increase rosuvastatin concentrations. Avoid concomitant use or limit rosuvastatin dose to 10 mg daily.
Cyclosporine
Coadministration significantly increases rosuvastatin exposure (up to 7-fold). Avoid combination.
Erythromycin
May decrease rosuvastatin exposure. Clinical significance is usually minimal.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. In case of overdose, provide symptomatic treatment and supportive measures. Hemodialysis is unlikely to be of benefit.
Pregnancy & Lactation
Contraindicated in pregnancy (Category X) and lactation due to potential harm to the fetus/infant. Women of childbearing potential should use adequate contraception.
Side Effects
Contraindications
- Active liver disease, including unexplained persistent elevations of serum transaminases
- Pregnancy
- Lactation
- Hypersensitivity to rosuvastatin or any component of the formulation
- Severe renal impairment (CrCl <30 mL/min)
Drug Interactions
Warfarin
May enhance the anticoagulant effect. INR monitoring required.
Gemfibrozil
May increase rosuvastatin concentrations. Avoid concomitant use or limit rosuvastatin dose to 10 mg daily.
Cyclosporine
Coadministration significantly increases rosuvastatin exposure (up to 7-fold). Avoid combination.
Erythromycin
May decrease rosuvastatin exposure. Clinical significance is usually minimal.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. In case of overdose, provide symptomatic treatment and supportive measures. Hemodialysis is unlikely to be of benefit.
Pregnancy & Lactation
Contraindicated in pregnancy (Category X) and lactation due to potential harm to the fetus/infant. Women of childbearing potential should use adequate contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent (generic available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of rosuvastatin in reducing lipid levels and cardiovascular events.
Lab Monitoring
- Liver function tests (LFTs) before initiation and periodically during treatment
- Creatine Kinase (CK) levels if muscle pain, tenderness, or weakness occurs
Doctor Notes
- Monitor LFTs regularly, especially at baseline and during dose titration.
- Counsel patients on reporting muscle symptoms promptly.
- Emphasize lifestyle modifications (diet, exercise) as adjuncts to therapy.
- Review concomitant medications for potential drug interactions.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Report any unexplained muscle pain, tenderness, or weakness immediately to your doctor.
- Avoid excessive alcohol consumption.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally, rosuvastatin does not affect the ability to drive or operate machinery. However, if you experience dizziness, do not drive or use machines.
Lifestyle Advice
- Maintain a low-fat and low-cholesterol diet.
- Engage in regular physical activity.
- Manage weight to a healthy level.
- Quit smoking.
- Control blood pressure and diabetes, if applicable.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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