Rotalac
Generic Name
Ketorolac Tromethamine
Manufacturer
Leading Pharmaceutical Manufacturer
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rotalac 10 mg tablet | ৳ 12.00 | ৳ 180.00 |
Description
Overview of the medicine
Rotalac 10 mg Tablet contains Ketorolac Tromethamine, a non-steroidal anti-inflammatory drug (NSAID) used for the short-term management of moderate to moderately severe acute pain. It works by reducing hormones that cause inflammation and pain in the body.
Uses & Indications
Dosage
Adults
Oral: 10 mg every 4-6 hours as needed, not to exceed 40 mg in 24 hours. Treatment duration should not exceed 5 days.
Elderly
Lower doses may be required (e.g., 10 mg every 6-8 hours). Use with caution and monitor renal function.
Renal_impairment
Dosage reduction is necessary. Contraindicated in severe renal impairment (creatinine clearance <30 mL/min).
How to Take
Take the tablet orally with a full glass of water. It can be taken with food or milk to minimize gastrointestinal upset.
Mechanism of Action
Ketorolac Tromethamine inhibits prostaglandin synthesis by blocking the enzyme cyclooxygenase (COX-1 and COX-2). This reduces the production of prostaglandins, which are involved in pain, inflammation, and fever.
Pharmacokinetics
Onset
Approximately 1 hour (oral).
Excretion
Mainly excreted in urine (91%), with a small portion (6%) excreted in feces. Renal clearance is the primary elimination route.
Half life
Approximately 4-6 hours.
Absorption
Rapidly and completely absorbed after oral administration. Peak plasma concentrations are reached within 30-60 minutes.
Metabolism
Primarily hepatic, mainly by glucuronidation. Some hydroxylation occurs.
Side Effects
Contraindications
- •Hypersensitivity to Ketorolac or other NSAIDs
- •Active peptic ulcer, gastrointestinal bleeding or perforation
- •Severe renal impairment or advanced renal disease
- •History of cerebrovascular bleeding or clotting disorders
- •Pregnancy (especially third trimester) and lactation
- •Concomitant use with other NSAIDs, aspirin, or anticoagulants
- •Before major surgery due to increased risk of bleeding
Drug Interactions
Lithium
Increased plasma lithium concentrations, potentially leading to toxicity.
SSRIs/SNRIs
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs/Aspirin
Increased risk of gastrointestinal side effects and bleeding.
ACE inhibitors/Diuretics
Reduced antihypertensive and diuretic effects, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, lethargy, and renal dysfunction. Management is primarily supportive; there is no specific antidote. Gastric decontamination (e.g., activated charcoal) may be considered if ingestion is recent.
Pregnancy & Lactation
Contraindicated during late pregnancy due to potential for premature closure of the fetal ductus arteriosus. Not recommended during breastfeeding as ketorolac is excreted in breast milk and may cause adverse effects in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved (Globally widely used)
Patent Status
Off-patent
WHO Essential Medicine
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Global Brand Names
International brand names for this medicine
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