Roxagen
Generic Name
Roxithromycin
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| roxagen 20 mg tablet | ৳ 180.00 | ৳ 540.00 |
| roxagen 50 mg tablet | ৳ 350.00 | ৳ 1,050.00 |
| roxagen 70 mg tablet | ৳ 450.00 | ৳ 1,350.00 |
| roxagen 100 mg tablet | ৳ 600.00 | ৳ 1,800.00 |
Description
Overview of the medicine
Roxagen (Roxithromycin) is a macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and certain genitourinary infections.
Uses & Indications
Dosage
Adults
150 mg twice daily or 300 mg once daily, preferably before meals. Duration usually 5-10 days, depending on infection.
Elderly
No specific dose adjustment is generally required, but caution advised in those with severe hepatic impairment.
Renal_impairment
No dose adjustment is usually required as only a small amount is excreted renally.
How to Take
Take Roxagen tablets orally, preferably at least 15 minutes before meals to ensure optimal absorption.
Mechanism of Action
Roxithromycin inhibits bacterial protein synthesis by reversibly binding to the 50S ribosomal subunit of susceptible microorganisms, thereby blocking transpeptidation.
Pharmacokinetics
Onset
Peak plasma concentrations are typically achieved within 1-2 hours after oral administration.
Excretion
Mainly excreted in faeces (approximately 65%), with a small amount (about 7-12%) excreted in urine.
Half life
Approximately 10-12 hours.
Absorption
Well absorbed orally, approximately 50% bioavailability. Food may delay absorption.
Metabolism
Primarily metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to roxithromycin, other macrolides, or any component of the formulation.
- Concomitant administration with ergot alkaloids (e.g., ergotamine, dihydroergotamine) due to potential for severe vasoconstriction.
- Concomitant administration with cisapride, pimozide, or terfenadine due to risk of QT prolongation and cardiac arrhythmias.
Drug Interactions
Digoxin
Increased digoxin levels, monitor digoxin concentrations.
Warfarin
Increased anticoagulant effect, monitor INR.
Midazolam
Increased sedative effect of midazolam.
Cyclosporine
Increased cyclosporine levels, monitor renal function and cyclosporine levels.
Ergot alkaloids
Severe peripheral vasoconstriction and ischemia (contraindicated).
Storage
Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage and symptomatic supportive measures should be taken. There is no specific antidote for roxithromycin.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use in pregnancy only if clearly needed. Roxithromycin is excreted in breast milk; therefore, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have established the efficacy and safety of roxithromycin in various bacterial infections. Further details can be found in peer-reviewed medical literature.
Lab Monitoring
- Liver function tests (LFTs) may be monitored, especially in patients with pre-existing hepatic impairment or during prolonged treatment.
Doctor Notes
- Advise patients to complete the entire course of antibiotics.
- Caution in patients with severe hepatic impairment.
- Be aware of potential drug interactions, especially with warfarin, digoxin, and cyclosporine.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if you feel better, to prevent antibiotic resistance.
- Do not share your medicine with others.
- Take the medicine consistently at the same time each day, preferably before meals.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.
Driving Precautions
Roxagen may cause dizziness or blurred vision in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Avoid alcohol consumption during treatment if experiencing gastrointestinal side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.