Roxen
Generic Name
Naproxen
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| roxen 500 mg tablet | ৳ 7.03 | ৳ 70.33 |
Description
Overview of the medicine
Naproxen is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, fever, swelling, and stiffness. It works by blocking the body's production of certain natural substances that cause inflammation.
Uses & Indications
Dosage
Adults
For pain/dysmenorrhea: 500 mg initially, then 250 mg every 6-8 hours as needed. Max 1250 mg/day for short term. For chronic conditions: 250-500 mg twice daily.
Elderly
Start with lower doses, closely monitor for adverse effects.
Renal_impairment
Caution advised, reduce dosage, monitor renal function. Avoid in severe renal impairment.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow whole with water. Do not crush or chew.
Mechanism of Action
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief within 1 hour.
Excretion
Excreted mainly in the urine (about 95%) as unchanged naproxen, 6-O-desmethylnaproxen, and their conjugates.
Half life
12-17 hours.
Absorption
Rapidly and completely absorbed from the GI tract. Peak plasma concentrations are achieved in 2-4 hours.
Metabolism
Primarily metabolized in the liver by demethylation and subsequent conjugation.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased lithium levels, leading to toxicity.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors/Diuretics
Reduced antihypertensive effect, increased risk of renal impairment.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, indigestion, nausea, vomiting. Severe overdose may cause gastrointestinal bleeding, acute renal failure, hypertension, respiratory depression, and coma. Management involves symptomatic and supportive measures. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Avoid in the third trimester due to risk of premature closure of fetal ductus arteriosus. Use with caution in first and second trimesters only if clearly needed. Excreted in breast milk, so caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased lithium levels, leading to toxicity.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors/Diuretics
Reduced antihypertensive effect, increased risk of renal impairment.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, indigestion, nausea, vomiting. Severe overdose may cause gastrointestinal bleeding, acute renal failure, hypertension, respiratory depression, and coma. Management involves symptomatic and supportive measures. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Avoid in the third trimester due to risk of premature closure of fetal ductus arteriosus. Use with caution in first and second trimesters only if clearly needed. Excreted in breast milk, so caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years
Availability
Pharmacies, Hospitals
Approval Status
DGDA approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in various pain and inflammatory conditions.
Lab Monitoring
- Complete blood count (CBC)
- renal function tests (serum creatinine, BUN)
- liver function tests (ALT, AST)
- stool occult blood tests
- blood pressure monitoring
Doctor Notes
- Advise patients on concomitant use of other NSAIDs or aspirin.
- Monitor patients with a history of GI issues or cardiovascular risk factors.
Patient Guidelines
- Take with food or milk.
- Do not exceed recommended dose.
- Report any signs of bleeding (e.g., black stools, vomiting blood).
- Avoid alcohol.
- Consult doctor if pregnant, breastfeeding, or have pre-existing medical conditions.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Patients should be cautioned about operating hazardous machinery or driving if they experience these effects.
Lifestyle Advice
- Maintain a balanced diet
- stay hydrated
- engage in moderate exercise (if appropriate for condition)
- Avoid smoking
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Global Brand Names
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