Administer orally. Can be taken at the start of a meal to minimize potential gastrointestinal intolerance. Swallow the tablet whole with a glass of water.

Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death. Clavulanic acid is a beta-lactamase inhibitor that inactivates a wide range of beta-lactamase enzymes produced by bacteria, thereby protecting amoxicillin from degradation and extending its antibacterial spectrum.

• •Known hypersensitivity to penicillin or other beta-lactam antibiotics
• •History of cholestatic jaundice/hepatic dysfunction associated with amoxicillin/clavulanate therapy
• •Severe renal impairment (CrCl < 30 mL/min) without dose adjustment

Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.

Symptoms of overdose include gastrointestinal symptoms such as nausea, vomiting, and diarrhea, and disturbances of fluid and electrolyte balance. Treatment is symptomatic and supportive; hemodialysis can remove amoxicillin/clavulanate from circulation.

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, use during pregnancy should only be when clearly needed. Both amoxicillin and clavulanic acid are excreted in breast milk; use with caution during lactation, monitoring for adverse effects in the infant.