Rozavas
Generic Name
Rosuvastatin 10 mg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rozavas 10 mg tablet | ৳ 24.00 | ৳ 240.00 |
Description
Overview of the medicine
Rosuvastatin is an HMG-CoA reductase inhibitor (statin) used to lower high cholesterol and triglyceride levels, and to reduce the risk of heart disease and stroke.
Uses & Indications
Dosage
Adults
Initial dose 5-10 mg once daily. Max dose 40 mg. The 10 mg tablet is a common starting dose.
Elderly
No specific dose adjustment generally needed, but caution with higher starting doses. Individualize dosage.
Renal_impairment
Mild-moderate: no adjustment. Severe (CrCl <30 mL/min): initiate 5 mg, max 10 mg daily.
How to Take
Take orally once daily, with or without food. Can be taken at any time of day, but consistency is recommended.
Mechanism of Action
Rosuvastatin selectively inhibits HMG-CoA reductase, an enzyme that catalyzes the early rate-limiting step in cholesterol biosynthesis. This leads to a decrease in hepatic cholesterol synthesis and an increase in the number of LDL receptors on the surface of liver cells, enhancing the uptake and catabolism of LDL.
Pharmacokinetics
Onset
Lipid-lowering effects typically within 1 week, maximal effect by 2-4 weeks.
Excretion
Primarily feces (90%), some urine (10%).
Half life
Approximately 19 hours.
Absorption
Approximately 20% bioavailability. Peak plasma concentration 3-5 hours.
Metabolism
Limited hepatic metabolism (CYP2C9, CYP3A4 minor pathway).
Side Effects
Contraindications
- Active liver disease, including unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
- Hypersensitivity to rosuvastatin or any component of the formulation
- Severe renal impairment (CrCl <30 mL/min) not on dialysis, especially with concomitant cyclosporine
Drug Interactions
Gemfibrozil
Increases rosuvastatin exposure; avoid co-administration. If co-administration is necessary, limit rosuvastatin to 10 mg once daily.
Cyclosporine
Concomitant use increases rosuvastatin exposure significantly; limit rosuvastatin to 5 mg once daily.
Erythromycin
Decreases rosuvastatin exposure.
Other fibrates
Increased risk of myopathy.
Niacin (lipid-lowering doses)
Increased risk of myopathy.
Ritonavir-boosted lopinavir/atazanavir
Significantly increases rosuvastatin exposure; limit rosuvastatin dose.
Coumarin anticoagulants (e.g., Warfarin)
May increase INR; monitor INR closely.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. In case of overdose, provide symptomatic treatment and supportive measures. Monitor liver function and CK levels.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to potential for fetal harm. Women of childbearing potential should use effective contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, hospitals
Approval Status
Approved by DGDA
Patent Status
Patent expired (Generic available)
Clinical Trials
Extensive clinical trials (e.g., JUPITER trial, AURORA trial) have demonstrated rosuvastatin's efficacy in reducing LDL-C and cardiovascular event risk across various patient populations.
Lab Monitoring
- Lipid profile (before treatment and periodically during treatment)
- Liver function tests (baseline and as clinically indicated)
- Creatine Kinase (CK) levels (baseline and if muscle symptoms occur)
Doctor Notes
- Counsel patients on lifestyle modifications (diet, exercise) as adjuncts to therapy.
- Emphasize reporting muscle symptoms promptly (pain, tenderness, weakness).
- Monitor LFTs and lipid profile regularly as per guidelines.
- Consider lower starting doses in Asian patients and those with severe renal impairment.
Patient Guidelines
- Take as prescribed, do not stop without consulting your doctor.
- Report any unexplained muscle pain, tenderness, or weakness immediately.
- Maintain a healthy diet and regular exercise as advised by your doctor.
- Avoid grapefruit juice (though less impact than other statins, general caution).
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at once.
Driving Precautions
Rosuvastatin is generally not expected to affect the ability to drive or operate machinery. However, patients should be aware of possible side effects like dizziness.
Lifestyle Advice
- Follow a low-fat, low-cholesterol diet.
- Engage in regular physical activity.
- Quit smoking and limit alcohol consumption.
- Manage stress effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.