Rozenon
Generic Name
Rosentan Hydrochloride 20 mg tablet
Manufacturer
PharmaCorp Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rozenon 20 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Rozenon 20 mg Tablet is an antidepressant medicine used to treat major depressive disorder, generalized anxiety disorder, and panic disorder.
Uses & Indications
Dosage
Adults
Initial dose 10 mg once daily, increased to 20 mg once daily after 1 week. Maximum 20 mg/day.
Elderly
Initial dose 5 mg once daily, gradually increased if needed. Maximum 10 mg/day.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Take orally with or without food, once daily, preferably at the same time each day.
Mechanism of Action
Rozenon is a Selective Serotonin Reuptake Inhibitor (SSRI). It works by increasing the levels of serotonin, a natural chemical in the brain that helps maintain mental balance, thereby improving mood and reducing anxiety.
Pharmacokinetics
Onset
Initial effects within 1-2 weeks; full therapeutic effect in 2-4 weeks.
Excretion
Primarily excreted via urine (metabolites) and feces.
Half life
Approximately 24-30 hours.
Absorption
Well absorbed orally, peak plasma concentrations typically reached within 4-6 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (e.g., CYP2C19, CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Rozenon or any component.
- Concomitant use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of stopping an MAOI.
- Concomitant use with Pimozide.
Drug Interactions
MAOIs
Risk of serotonin syndrome.
NSAIDs
Increased risk of gastrointestinal bleeding.
Warfarin
May increase anticoagulant effect.
Tricyclic Antidepressants (TCAs)
Increased plasma levels of TCAs.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include dizziness, tremor, nausea, vomiting, tachycardia. Management is symptomatic and supportive; ensure airway, breathing, and circulation. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Category C in pregnancy. Use only if potential benefit justifies potential risk. Avoid during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Rozenon or any component.
- Concomitant use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of stopping an MAOI.
- Concomitant use with Pimozide.
Drug Interactions
MAOIs
Risk of serotonin syndrome.
NSAIDs
Increased risk of gastrointestinal bleeding.
Warfarin
May increase anticoagulant effect.
Tricyclic Antidepressants (TCAs)
Increased plasma levels of TCAs.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include dizziness, tremor, nausea, vomiting, tachycardia. Management is symptomatic and supportive; ensure airway, breathing, and circulation. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Category C in pregnancy. Use only if potential benefit justifies potential risk. Avoid during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Patent pending
Clinical Trials
Extensive Phase I, II, and III clinical trials demonstrated efficacy and safety in major depressive disorder and anxiety disorders.
Lab Monitoring
- Monitor for hyponatremia, especially in elderly patients.
- Periodic liver function tests for long-term use.
Doctor Notes
- Counsel patients on delayed onset of action and importance of adherence.
- Assess for suicidal ideation, especially at initiation and dose changes.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking abruptly without consulting your doctor to avoid withdrawal symptoms.
- It may take several weeks to feel the full benefits.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Avoid alcohol consumption during treatment.
- Engage in regular exercise and maintain a balanced diet for better mental health.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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