Rubitor
Generic Name
Rubitoxate Sodium
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rubitor 2 mg injection | ৳ 950.00 | N/A |
Description
Overview of the medicine
Rubitor 2 mg Injection contains Rubitoxate Sodium, a selective COX-2 inhibitor, used for the rapid relief of pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and acute musculoskeletal disorders.
Uses & Indications
Dosage
Adults
2 mg once daily, administered intramuscularly or intravenously. Maximum daily dose is 4 mg in divided doses if necessary, for short-term use.
Elderly
Generally, lower doses may be required, considering potential renal or hepatic impairment. Start with 1 mg once daily.
Renal_impairment
Use with caution in mild to moderate impairment. Not recommended in severe renal impairment (CrCl < 30 mL/min). Dosage adjustment may be necessary, e.g., 1 mg once daily.
How to Take
Rubitor 2 mg Injection should be administered slowly by intramuscular (IM) or intravenous (IV) injection by a healthcare professional. For IV administration, it may be diluted in normal saline or 5% dextrose solution.
Mechanism of Action
Rubitoxate Sodium selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins, mediators of pain and inflammation. By inhibiting COX-2, it reduces prostaglandin production, thereby alleviating pain and inflammation with potentially fewer gastrointestinal side effects compared to non-selective NSAIDs.
Pharmacokinetics
Onset
Within 30 minutes after injection.
Excretion
Excreted mainly via urine (approximately 60%) and feces (approximately 40%) as metabolites.
Half life
Approximately 4-6 hours.
Absorption
Rapidly absorbed after intramuscular or intravenous administration, reaching peak plasma concentrations within 15-30 minutes.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes (e.g., CYP2C9).
Side Effects
Contraindications
- Known hypersensitivity to Rubitoxate Sodium or any other NSAID, including aspirin.
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
- Severe heart failure, severe renal impairment, or severe hepatic impairment.
- Active gastrointestinal bleeding or peptic ulcer.
- Third trimester of pregnancy.
Drug Interactions
Lithium
Decreased renal clearance of lithium, leading to increased plasma lithium levels and potential toxicity.
Methotrexate
Increased plasma levels of methotrexate, leading to increased toxicity.
Diuretics and ACE inhibitors
Reduced natriuretic effect of diuretics and antihypertensive effect of ACE inhibitors. May lead to renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding. Close monitoring of INR is required.
Other NSAIDs or corticosteroids
Increased risk of gastrointestinal adverse effects.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is supportive and symptomatic; there is no specific antidote. Gastric lavage and activated charcoal may be considered if taken orally, but for injection, focus on supportive care.
Pregnancy & Lactation
Pregnancy Category C in the first and second trimesters, D in the third trimester. Avoid use in late pregnancy due to potential fetal adverse effects. Use with caution during lactation; consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to Rubitoxate Sodium or any other NSAID, including aspirin.
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
- Severe heart failure, severe renal impairment, or severe hepatic impairment.
- Active gastrointestinal bleeding or peptic ulcer.
- Third trimester of pregnancy.
Drug Interactions
Lithium
Decreased renal clearance of lithium, leading to increased plasma lithium levels and potential toxicity.
Methotrexate
Increased plasma levels of methotrexate, leading to increased toxicity.
Diuretics and ACE inhibitors
Reduced natriuretic effect of diuretics and antihypertensive effect of ACE inhibitors. May lead to renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding. Close monitoring of INR is required.
Other NSAIDs or corticosteroids
Increased risk of gastrointestinal adverse effects.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is supportive and symptomatic; there is no specific antidote. Gastric lavage and activated charcoal may be considered if taken orally, but for injection, focus on supportive care.
Pregnancy & Lactation
Pregnancy Category C in the first and second trimesters, D in the third trimester. Avoid use in late pregnancy due to potential fetal adverse effects. Use with caution during lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by Regulatory Authority (e.g., DGDA)
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of Rubitoxate Sodium in reducing acute pain and inflammation, with studies showing comparable efficacy to other NSAIDs but with a potentially improved gastrointestinal tolerability profile.
Lab Monitoring
- Renal function (BUN, creatinine) periodically, especially in elderly or patients with pre-existing renal impairment.
- Liver function tests (ALT, AST) periodically.
- Complete blood count (CBC) for signs of anemia or bleeding.
Doctor Notes
- Assess patient's cardiovascular and gastrointestinal risk factors before initiating therapy.
- Monitor renal function, liver enzymes, and blood pressure during treatment.
- Use the lowest effective dose for the shortest possible duration to minimize risks.
Patient Guidelines
- This medicine will be administered by a healthcare professional.
- Report any unusual side effects or worsening of symptoms immediately.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
As this medicine is administered by a healthcare professional, a missed dose is unlikely. If a scheduled dose is missed, contact your doctor or nurse to reschedule.
Driving Precautions
Rubitor may cause dizziness or visual disturbances. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid alcohol consumption while on this medication, especially if you have a history of gastrointestinal issues.
- Follow up with your doctor as advised.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.