Rupaset
Generic Name
Rupatadine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rupaset 10 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Rupatadine is a second-generation antihistamine used for the symptomatic treatment of seasonal and perennial allergic rhinitis and urticaria in adults and adolescents (aged 12 years and above). It has selective peripheral H1-receptor antagonist activity and also acts as a platelet-activating factor (PAF) antagonist.
Uses & Indications
Dosage
Adults
10 mg once daily, taken with or without food.
Elderly
No dose adjustment is generally required, but caution should be exercised in elderly patients with renal or hepatic impairment due to limited clinical experience.
Renal_impairment
Use with caution in patients with severe renal impairment. Dose adjustment may be necessary in severe cases.
How to Take
Oral administration, with or without food.
Mechanism of Action
Rupatadine is a long-acting, non-sedating, selective peripheral H1-receptor antagonist. It also has antagonistic activity against platelet-activating factor (PAF) and inhibits the degranulation of mast cells and eosinophils, contributing to its anti-allergic and anti-inflammatory effects.
Pharmacokinetics
Onset
Onset of action typically within 1 hour.
Excretion
Approximately 60.9% excreted via feces and 34.6% via urine over 7 days, primarily as metabolites.
Half life
The elimination half-life of rupatadine is approximately 5.9 hours (for parent compound) and approximately 15.9 hours (for active metabolites).
Absorption
Rapidly absorbed after oral administration. Mean Cmax achieved approximately 0.75-1.5 hours after intake.
Metabolism
Extensively metabolized by the liver, primarily via CYP3A4, into several active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to rupatadine or to any of the excipients.
Drug Interactions
CNS depressants (e.g., Alcohol, Benzodiazepines)
May enhance the sedative effects of rupatadine.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin, Grapefruit juice)
Can increase systemic exposure of rupatadine, potentially leading to increased adverse effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for rupatadine. Gastric lavage and activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy Category B. It is advisable to avoid rupatadine during pregnancy unless clearly necessary. It is unknown whether rupatadine is excreted in human breast milk; therefore, caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to rupatadine or to any of the excipients.
Drug Interactions
CNS depressants (e.g., Alcohol, Benzodiazepines)
May enhance the sedative effects of rupatadine.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin, Grapefruit juice)
Can increase systemic exposure of rupatadine, potentially leading to increased adverse effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for rupatadine. Gastric lavage and activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy Category B. It is advisable to avoid rupatadine during pregnancy unless clearly necessary. It is unknown whether rupatadine is excreted in human breast milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of rupatadine in the symptomatic treatment of allergic rhinitis and urticaria, showing significant improvement in symptom scores compared to placebo.
Lab Monitoring
- No specific routine lab monitoring is required for rupatadine in patients with normal renal and hepatic function.
Doctor Notes
- Use with caution in patients with known or suspected prolongation of the QT interval, uncorrected hypokalemia, or persistent bradydysrhythmias.
- Exercise caution in patients with hepatic and renal insufficiency, especially severe impairment, as dose adjustment may be necessary and clinical experience is limited.
- Advise patients to avoid alcohol and grapefruit juice during treatment.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all medicines you are taking, including over-the-counter drugs and herbal supplements.
- Avoid consumption of alcohol while taking this medicine as it may increase sedative effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Rupatadine may cause drowsiness or dizziness. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Identify and avoid known allergens (e.g., pollen, dust mites, pet dander) that trigger your allergic symptoms.
- Maintain a healthy lifestyle to support overall well-being.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.