Rupastar
Generic Name
Rupatadine
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rupastar 10 mg tablet | ৳ 10.00 | N/A |
Description
Overview of the medicine
Rupastar 10 mg Tablet contains Rupatadine, a second-generation antihistamine used to relieve symptoms of allergic rhinitis (e.g., sneezing, runny nose, itchy eyes) and chronic idiopathic urticaria (hives) in adults and adolescents 12 years and older.
Uses & Indications
Dosage
Adults
10 mg once daily, with or without food.
Elderly
No specific dose adjustment is generally required. Use with caution due to potential age-related decrease in renal or hepatic function.
Renal_impairment
Use with caution in patients with renal impairment. Not recommended in patients with severe renal impairment.
Hepatic_impairment
Use with caution in patients with hepatic impairment. Not recommended in patients with severe hepatic impairment.
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Rupatadine is a long-acting, selective peripheral H1-receptor antagonist. It also has antagonistic activity against platelet-activating factor (PAF), further contributing to its anti-allergic effects.
Pharmacokinetics
Onset
Onset of action typically occurs within 1 hour.
Excretion
Approximately 60.9% of the dose is excreted via feces and 34.6% via urine, mainly as metabolites.
Half life
The elimination half-life of rupatadine is approximately 5.9 hours (for the parent drug).
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations (Cmax) are reached approximately 0.75-1.5 hours post-dose. Extensive first-pass metabolism occurs.
Metabolism
Extensively metabolized by the cytochrome P450 system (primarily CYP3A4) into active and inactive metabolites, including desloratadine.
Side Effects
Contraindications
- Hypersensitivity to rupatadine or any other component of the tablet
- Children under 12 years of age
Drug Interactions
Statins
Rupatadine should be administered with caution when co-administered with statins as they are also metabolized by CYP3A4.
CNS depressants (e.g., alcohol, benzodiazepines)
May enhance the sedative effects of CNS depressants. Avoid concurrent use with alcohol.
Ketoconazole, Erythromycin, Clarithromycin, Itraconazole
Concurrent administration with strong CYP3A4 inhibitors may increase systemic exposure to rupatadine. Use with caution.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. In case of overdose, symptomatic and supportive treatment should be initiated. No specific antidote is available.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed after careful assessment of benefits and risks. It is not known whether rupatadine is excreted in human milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to rupatadine or any other component of the tablet
- Children under 12 years of age
Drug Interactions
Statins
Rupatadine should be administered with caution when co-administered with statins as they are also metabolized by CYP3A4.
CNS depressants (e.g., alcohol, benzodiazepines)
May enhance the sedative effects of CNS depressants. Avoid concurrent use with alcohol.
Ketoconazole, Erythromycin, Clarithromycin, Itraconazole
Concurrent administration with strong CYP3A4 inhibitors may increase systemic exposure to rupatadine. Use with caution.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. In case of overdose, symptomatic and supportive treatment should be initiated. No specific antidote is available.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed after careful assessment of benefits and risks. It is not known whether rupatadine is excreted in human milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Pharmacies
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety of rupatadine in the symptomatic treatment of allergic rhinitis and chronic urticaria. Post-marketing surveillance continues to monitor for rare adverse effects.
Lab Monitoring
- No specific laboratory monitoring is typically required for routine use. Liver function tests may be considered in patients with pre-existing hepatic impairment or prolonged use.
Doctor Notes
- Advise patients regarding potential drowsiness and to avoid activities requiring mental alertness, especially at the start of treatment.
- Caution in patients with prolonged QT interval, uncorrected hypokalemia, or other proarrhythmic conditions, though a significant effect on QT interval is not expected at therapeutic doses.
- Not recommended for patients with severe hepatic or renal impairment due to lack of data.
Patient Guidelines
- Take one tablet once daily as prescribed by your doctor.
- Do not exceed the recommended dose.
- Avoid consumption of alcohol while taking this medicine.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause drowsiness. Avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain good indoor air quality and hygiene to reduce exposure to allergens.
- Consult your doctor if symptoms persist or worsen despite medication.
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Global Brand Names
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