Rupatid
Generic Name
Rupatadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rupatid 10 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Rupatadine is a second-generation, non-sedating antihistamine that also has platelet-activating factor (PAF) antagonistic activity. It is used for the symptomatic treatment of seasonal and perennial allergic rhinitis and urticaria.
Uses & Indications
Dosage
Adults
10 mg once daily, with or without food.
Elderly
No specific dose adjustment is required in elderly patients, but caution should be exercised due to potential for decreased renal/hepatic function.
Renal_impairment
Use with caution in patients with renal impairment. No specific dose adjustment guidelines are available, but dosage should be individualized based on clinical response and tolerability.
Hepatic_impairment
Use with caution in patients with hepatic impairment. No specific dose adjustment guidelines are available, but dosage should be individualized based on clinical response and tolerability.
How to Take
Take the tablet orally with a glass of water, with or without food. Do not chew or crush the tablet.
Mechanism of Action
Rupatadine selectively antagonizes peripheral H1-histamine receptors. It also inhibits the degranulation of mast cells and basophils, reduces the release of cytokines, and has anti-inflammatory properties through its PAF antagonistic effect.
Pharmacokinetics
Onset
Onset of antihistaminic effect typically occurs within 1 to 2 hours.
Excretion
Approximately 60% of rupatadine is excreted in feces and 40% in urine as metabolites. Only a very small fraction is excreted unchanged.
Half life
The mean elimination half-life is approximately 5.9 hours.
Absorption
Rupatadine is rapidly absorbed after oral administration. Peak plasma concentration is reached approximately 0.75-1.5 hours after intake. Bioavailability is low (around 10-20%) due to extensive first-pass metabolism.
Metabolism
Rupatadine undergoes extensive metabolism primarily by the cytochrome P450 (CYP3A4) system, forming several active and inactive metabolites, including desloratadine and 3-hydroxydesloratadine.
Side Effects
Contraindications
- Hypersensitivity to rupatadine or to any of the excipients.
- Patients with known prolonged QT interval (due to potential for QT prolongation with other antihistamines).
Drug Interactions
Statins
Rupatadine is metabolized by CYP3A4, which also metabolizes statins. There is a theoretical risk of increased statin levels, though clinical significance is unknown.
Diltiazem
A moderate CYP3A4 inhibitor, may increase rupatadine's systemic exposure. Caution advised.
Ketoconazole and Erythromycin
These potent CYP3A4 inhibitors increase rupatadine's systemic exposure. Co-administration should be avoided or used with caution, requiring dose reduction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, headache, dry mouth, fatigue, and possibly increased heart rate. Treatment should be symptomatic and supportive. Gastric lavage and activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy: Category B. Animal studies have shown no evidence of fetal harm, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Lactation: It is unknown whether rupatadine is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent in many regions
Clinical Trials
Rupatadine has been evaluated in numerous clinical trials demonstrating its efficacy and safety in the treatment of allergic rhinitis and chronic urticaria across various populations. These trials support its profile as a non-sedating antihistamine with anti-PAF properties.
Lab Monitoring
- Generally, no routine laboratory monitoring is required. Liver function tests may be considered in patients with pre-existing hepatic impairment.
Doctor Notes
- Advise patients about potential drowsiness, especially when initiating therapy.
- Caution patients about grapefruit juice and potential drug interactions with CYP3A4 inhibitors.
- Consider alternative therapies or dose adjustments in patients with significant hepatic or renal impairment.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid consumption of alcohol while taking this medicine.
- If symptoms persist or worsen, consult your doctor.
- Inform your doctor about all other medicines you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Rupatadine may cause drowsiness or dizziness in some individuals. Patients should be advised not to drive or operate machinery until they know how they react to the medication.
Lifestyle Advice
- Identify and avoid exposure to known allergens that trigger your symptoms.
- Maintain good personal hygiene, especially during allergy seasons.
- Stay hydrated and ensure adequate rest.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.