Rupsol
Generic Name
Rupsol-5-Oral-Paste
Manufacturer
Reputable Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rupsol 5 oral paste | ৳ 75.00 | N/A |
Description
Overview of the medicine
Rupsol-5-Oral-Paste is a corticosteroid preparation indicated for the symptomatic treatment of inflammatory and ulcerative lesions of the oral mucosa. It helps to reduce inflammation, swelling, and discomfort associated with various oral conditions.
Uses & Indications
Dosage
Adults
Apply a small amount (about 0.25 inch) to the affected area at bedtime, and if necessary, 2 or 3 times daily, preferably after meals. Do not rub in.
Elderly
No specific dose adjustment is generally required for elderly patients; use as for adults.
Renal_impairment
No specific dose adjustment is generally required for patients with renal impairment due to minimal systemic absorption.
How to Take
Apply a small amount to the affected area without rubbing until a thin film develops. It should be applied at bedtime to permit prolonged contact with the lesion, and if necessary, 2 or 3 times daily after meals. The paste adheres to moist tissue, forming a protective film.
Mechanism of Action
Triamcinolone acetonide, a synthetic corticosteroid, works by diffusing across cell membranes and complexing with specific cytoplasmic receptors. These complexes then enter the nucleus, bind to DNA (chromatin), and stimulate the transcription of mRNA, which in turn leads to the synthesis of certain proteins (e.g., lipocortins). Lipocortins inhibit phospholipase A2, thereby inhibiting the synthesis of inflammatory mediators like prostaglandins and leukotrienes. This results in anti-inflammatory, anti-allergic, and vasoconstrictive effects, reducing edema and pain.
Pharmacokinetics
Onset
Within hours of application, symptomatic relief may be observed.
Excretion
Excreted mainly via urine as metabolites.
Half life
Not well established for topical oral use due to minimal systemic absorption.
Absorption
Minimal systemic absorption occurs following topical application to the oral mucosa. Any absorbed drug is rapidly metabolized.
Metabolism
Primarily hepatic metabolism for any systemically absorbed portion.
Side Effects
Contraindications
- Patients with a history of hypersensitivity to triamcinolone acetonide or any component of the formulation.
- Oral fungal, viral (e.g., herpes simplex), or bacterial infections.
- Tuberculosis of the oral cavity.
Drug Interactions
Immunosuppressants
The local immunosuppressive effect might be additive, but systemic interactions are minimal.
Systemic Corticosteroids
Increased risk of systemic corticosteroid effects if significant absorption occurs, though unlikely with topical oral use.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose with topical oral triamcinolone acetonide is unlikely due to minimal systemic absorption. In case of accidental ingestion of a large amount, symptomatic and supportive measures may be considered.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether topical corticosteroids are excreted in human milk. Consult a doctor.
Side Effects
Contraindications
- Patients with a history of hypersensitivity to triamcinolone acetonide or any component of the formulation.
- Oral fungal, viral (e.g., herpes simplex), or bacterial infections.
- Tuberculosis of the oral cavity.
Drug Interactions
Immunosuppressants
The local immunosuppressive effect might be additive, but systemic interactions are minimal.
Systemic Corticosteroids
Increased risk of systemic corticosteroid effects if significant absorption occurs, though unlikely with topical oral use.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose with topical oral triamcinolone acetonide is unlikely due to minimal systemic absorption. In case of accidental ingestion of a large amount, symptomatic and supportive measures may be considered.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether topical corticosteroids are excreted in human milk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by Regulatory Authority
Patent Status
Patent Expired
Clinical Trials
Extensive clinical trials have established the efficacy and safety of triamcinolone acetonide oral paste for inflammatory oral lesions. Studies generally focus on local efficacy and minimal systemic absorption.
Lab Monitoring
- Not routinely required for typical topical oral use.
- For prolonged or extensive use, monitoring for systemic corticosteroid effects (e.g., adrenal function tests) may be considered, especially in children.
Doctor Notes
- Emphasize the importance of correct application technique (dab, do not rub).
- Advise patients on short-term use to minimize risk of local side effects and candidiasis.
- Rule out underlying infections before prescribing.
Patient Guidelines
- Do not rub the paste into the lesion; simply apply a small dab.
- Wash hands thoroughly before and after application.
- Avoid eating or drinking for at least 30 minutes after application to allow the paste to adhere and act.
- Do not exceed the recommended dose or duration of treatment.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not apply extra paste to make up for a missed dose.
Driving Precautions
Rupsol-5-Oral-Paste is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good oral hygiene.
- Avoid irritants like very hot, spicy, or acidic foods if they worsen oral lesions.
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