Rymin
Generic Name
Cyproheptadine Hydrochloride Syrup
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rymin 10 mg syrup | ৳ 45.00 | N/A |
Description
Overview of the medicine
Rymin syrup contains Cyproheptadine Hydrochloride, an antihistamine used to relieve symptoms of various allergic conditions and also functions as an appetite stimulant.
Uses & Indications
Dosage
Adults
Typically, 4 mg (10 ml) three times daily. Maximum recommended daily dose is 32 mg.
Elderly
Start with a lower dose (e.g., 2 mg 2-3 times daily) and adjust based on response and tolerability due to increased sensitivity to side effects.
Renal_impairment
Use with caution. Dosage adjustment may be necessary in severe renal impairment.
How to Take
For oral administration. Can be taken with or without food. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Cyproheptadine acts as a potent H1-histamine receptor antagonist, thereby blocking the effects of histamine. It also possesses antiserotonergic and anticholinergic properties.
Pharmacokinetics
Onset
Onset of action is typically within 15-30 minutes.
Excretion
Excreted primarily via the kidneys (urine), with some excretion in feces.
Half life
Elimination half-life ranges from 8 to 16 hours.
Absorption
Well absorbed from the gastrointestinal tract following oral administration.
Metabolism
Extensively metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to cyproheptadine or any component of the formulation
- Acute asthma attack
- Narrow-angle glaucoma
- Symptomatic prostatic hypertrophy
- Bladder neck obstruction
- Stenosing peptic ulcer
- Concomitant use with MAOIs (monoamine oxidase inhibitors)
- Newborn or premature infants
Drug Interactions
MAO Inhibitors
May prolong and intensify the anticholinergic and CNS depressant effects of cyproheptadine.
CNS Depressants (e.g., alcohol, sedatives, hypnotics)
May enhance CNS depressant effects, leading to increased drowsiness or sedation.
Anticholinergics (e.g., tricyclic antidepressants, atropine)
May increase the risk of anticholinergic side effects like dry mouth, urinary retention, and blurred vision.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose include severe drowsiness, dizziness, confusion, dry mouth, dilated pupils, flushed skin, fever, hallucinations, convulsions, and coma. Treatment is symptomatic and supportive, including gastric lavage or activated charcoal. Naloxone may be used to reverse CNS depression in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of fetal harm, but adequate and well-controlled studies in pregnant women are lacking. Use only if clearly needed. Lactation: It is unknown whether cyproheptadine is excreted in human milk. Due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to cyproheptadine or any component of the formulation
- Acute asthma attack
- Narrow-angle glaucoma
- Symptomatic prostatic hypertrophy
- Bladder neck obstruction
- Stenosing peptic ulcer
- Concomitant use with MAOIs (monoamine oxidase inhibitors)
- Newborn or premature infants
Drug Interactions
MAO Inhibitors
May prolong and intensify the anticholinergic and CNS depressant effects of cyproheptadine.
CNS Depressants (e.g., alcohol, sedatives, hypnotics)
May enhance CNS depressant effects, leading to increased drowsiness or sedation.
Anticholinergics (e.g., tricyclic antidepressants, atropine)
May increase the risk of anticholinergic side effects like dry mouth, urinary retention, and blurred vision.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose include severe drowsiness, dizziness, confusion, dry mouth, dilated pupils, flushed skin, fever, hallucinations, convulsions, and coma. Treatment is symptomatic and supportive, including gastric lavage or activated charcoal. Naloxone may be used to reverse CNS depression in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of fetal harm, but adequate and well-controlled studies in pregnant women are lacking. Use only if clearly needed. Lactation: It is unknown whether cyproheptadine is excreted in human milk. Due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic
Clinical Trials
Cyproheptadine is an older, well-established drug, and most of its clinical efficacy and safety data come from historical trials and extensive clinical experience. Newer trials might focus on specific off-label uses or comparisons with other agents.
Lab Monitoring
- No routine lab monitoring is generally required. For long-term use, especially in children, periodic monitoring of growth parameters and liver function tests may be considered.
Doctor Notes
- Counsel patients on potential sedation and instruct them to avoid driving or hazardous activities.
- When used as an appetite stimulant, monitor weight gain and overall nutritional status.
- Caution in elderly patients and those with underlying conditions like glaucoma or prostatic hypertrophy due to anticholinergic effects.
Patient Guidelines
- Do not exceed the prescribed dose.
- Avoid driving or operating machinery until you know how the medicine affects you, as it may cause drowsiness.
- Avoid alcohol consumption while taking this medicine.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
Rymin syrup may cause drowsiness, dizziness, or blurred vision. Patients should be warned about engaging in activities requiring mental alertness, such as driving or operating machinery, until they know how the drug affects them.
Lifestyle Advice
- Maintain good hydration to counter dry mouth.
- In case of appetite stimulation, ensure a balanced and nutritious diet.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.