s-fluclox
Generic Name
Flucloxacillin 250 mg Capsule
Manufacturer
XYZ Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| s fluclox 250 mg capsule | ৳ 7.00 | N/A |
Description
Overview of the medicine
Flucloxacillin is a narrow-spectrum beta-lactam antibiotic of the penicillin class. It is used to treat bacterial infections such as skin and soft tissue infections, bone infections, and endocarditis. It is effective against Gram-positive bacteria, particularly penicillin-resistant staphylococci.
Uses & Indications
Dosage
Adults
250-500 mg every 6 hours, orally, depending on the severity of infection. Higher doses may be used for severe infections.
Elderly
No specific dose adjustment for elderly with normal renal function, but monitor renal function.
Renal_impairment
Dosage adjustment required. For severe renal impairment (creatinine clearance < 10 ml/min), a reduced dose or extended dosing interval may be necessary.
How to Take
Take on an empty stomach, at least 30-60 minutes before food, for optimal absorption. Swallow the capsule whole with water.
Mechanism of Action
Flucloxacillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and bacterial death. It is resistant to degradation by beta-lactamase enzymes produced by staphylococci.
Pharmacokinetics
Onset
Rapid, typically within 1 hour.
Excretion
Primarily excreted unchanged in the urine, with some biliary excretion.
Half life
Approximately 0.5-1.5 hours in adults with normal renal function.
Absorption
Well absorbed orally, peak plasma concentrations reached within 1-2 hours. Food may reduce absorption.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Flucloxacillin or any other penicillin antibiotic
- History of flucloxacillin-associated jaundice/hepatic dysfunction
Drug Interactions
Warfarin
May increase anticoagulant effect (monitor INR).
Probenecid
Increases and prolongs plasma levels of flucloxacillin.
Methotrexate
May increase methotrexate toxicity.
Oral Contraceptives
May reduce efficacy (use alternative contraception).
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal disturbances, electrolyte imbalance, and in rare cases, renal failure or convulsions. Treatment is supportive, including gastric lavage or activated charcoal if recent ingestion, and symptomatic management.
Pregnancy & Lactation
Flucloxacillin is generally considered safe during pregnancy when clinically indicated. It is excreted in small amounts in breast milk; generally considered safe during lactation, but monitor for adverse effects in the infant (e.g., diarrhea, candidiasis).
Side Effects
Contraindications
- Hypersensitivity to Flucloxacillin or any other penicillin antibiotic
- History of flucloxacillin-associated jaundice/hepatic dysfunction
Drug Interactions
Warfarin
May increase anticoagulant effect (monitor INR).
Probenecid
Increases and prolongs plasma levels of flucloxacillin.
Methotrexate
May increase methotrexate toxicity.
Oral Contraceptives
May reduce efficacy (use alternative contraception).
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal disturbances, electrolyte imbalance, and in rare cases, renal failure or convulsions. Treatment is supportive, including gastric lavage or activated charcoal if recent ingestion, and symptomatic management.
Pregnancy & Lactation
Flucloxacillin is generally considered safe during pregnancy when clinically indicated. It is excreted in small amounts in breast milk; generally considered safe during lactation, but monitor for adverse effects in the infant (e.g., diarrhea, candidiasis).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of flucloxacillin for its approved indications, especially against penicillin-resistant Staphylococcus aureus infections.
Lab Monitoring
- Liver function tests (especially with prolonged use or in patients with liver impairment)
- Renal function tests (in patients with renal impairment)
- Complete blood count (for prolonged therapy)
Doctor Notes
- Always confirm patient's penicillin allergy status before prescribing.
- Advise patients to report any signs of jaundice or severe rash immediately.
- Consider renal dose adjustment in elderly or renally impaired patients.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if you feel better.
- Do not share this medicine with others.
- Inform your doctor about any allergies or medical conditions.
- Take on an empty stomach.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally not expected to affect ability to drive or operate machinery. However, if you experience dizziness or other side effects, avoid driving.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Stay hydrated.
- Avoid alcohol during treatment as it may exacerbate side effects.
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