Salocin
Generic Name
Salocin-200-mg-tablet
Manufacturer
Alpha Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| salocin 200 mg tablet | ৳ 17.05 | N/A |
Description
Overview of the medicine
Salocin 200 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and fever. It provides effective relief from various conditions such as osteoarthritis, rheumatoid arthritis, dysmenorrhea, and general body aches.
Uses & Indications
Dosage
Adults
Oral: 200 mg every 4-6 hours as needed. Maximum 1200 mg in 24 hours.
Elderly
Start with a lower dose (e.g., 100 mg every 6-8 hours) and monitor for adverse effects due to increased sensitivity and potential for renal impairment.
Renal_impairment
Use with caution. Dosage reduction may be required based on creatinine clearance. Avoid in severe renal impairment.
How to Take
Take Salocin 200 mg Tablet orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Salocin works by inhibiting the activity of cyclooxygenase (COX) enzymes, particularly COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever, thus reducing their levels alleviates symptoms.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Mainly excreted by the kidneys (approximately 60-70%) and a smaller portion through feces.
Half life
Approximately 2-4 hours
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations (Cmax) achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver via cytochrome P450 (CYP) enzymes, leading to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Salocin or other NSAIDs (e.g., aspirin, ibuprofen)
- History of gastrointestinal bleeding or peptic ulceration
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Severe heart failure
Drug Interactions
Lithium
Increased plasma lithium levels.
ACE Inhibitors / Diuretics
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and headache. More severe symptoms like gastrointestinal bleeding, acute renal failure, and respiratory depression may occur. Management involves symptomatic and supportive treatment; gastric lavage or activated charcoal may be considered within the first hour.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during lactation; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Salocin or other NSAIDs (e.g., aspirin, ibuprofen)
- History of gastrointestinal bleeding or peptic ulceration
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Severe heart failure
Drug Interactions
Lithium
Increased plasma lithium levels.
ACE Inhibitors / Diuretics
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and headache. More severe symptoms like gastrointestinal bleeding, acute renal failure, and respiratory depression may occur. Management involves symptomatic and supportive treatment; gastric lavage or activated charcoal may be considered within the first hour.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired
Clinical Trials
Phase III clinical trials demonstrated Salocin's efficacy and safety in treating mild to moderate pain and inflammation, supporting its approval for the listed indications.
Lab Monitoring
- Regular monitoring of renal function (creatinine, BUN)
- Liver function tests (ALT, AST) for long-term use
- Complete Blood Count (CBC) for signs of anemia due to GI bleeding
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration.
- Evaluate cardiovascular and gastrointestinal risk factors before initiating therapy.
- Monitor renal function, especially in elderly or renally impaired patients.
Patient Guidelines
- Take with food or milk to reduce stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor if you experience severe stomach pain, black stools, or unusual bleeding/bruising.
- Avoid concurrent use with other NSAIDs without consulting a doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Salocin may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Limit alcohol intake during treatment. Stay hydrated. Follow a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.