Salost
Generic Name
Salbutamol (Albuterol)
Manufacturer
Various (e.g., GlaxoSmithKline originally)
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| salost 5 mg tablet | ৳ 8.00 | ৳ 56.00 |
Description
Overview of the medicine
Salost 5 mg Tablet contains Salbutamol (also known as Albuterol), which is a short-acting beta-2 agonist (SABA) bronchodilator. It is used to relieve symptoms of asthma and chronic obstructive pulmonary disease (COPD) such as wheezing, shortness of breath, and chest tightness.
Uses & Indications
Dosage
Adults
Oral: 2 mg to 4 mg three or four times daily. In some cases, doses up to 8 mg four times daily may be used. 5 mg tablet is often used for severe conditions or as prescribed by a physician.
Elderly
Lower initial doses may be considered, e.g., 2 mg three or four times daily, with careful titration based on response and tolerability.
Renal_impairment
No specific dose adjustment is generally required, but caution is advised in severe renal impairment.
How to Take
Take the tablet whole with water. It can be taken with or without food. Follow your doctor's instructions.
Mechanism of Action
Salbutamol selectively stimulates beta-2 adrenergic receptors in the smooth muscle of the bronchi, leading to relaxation of the bronchial smooth muscle and bronchodilation. This helps to open the airways and improve breathing.
Pharmacokinetics
Onset
5-15 minutes (oral tablet)
Excretion
Mainly excreted in the urine as metabolites and unchanged drug.
Half life
Approximately 4-6 hours
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations occur within 2-3 hours.
Metabolism
Primarily hepatic metabolism to an inactive sulfate conjugate.
Side Effects
Contraindications
- Hypersensitivity to salbutamol or any component of the formulation
- Threatened abortion (oral salbutamol preparations are contraindicated)
Drug Interactions
Digoxin
May decrease serum digoxin levels.
Diuretics
May cause ECG changes and/or hypokalemia, especially with high doses of beta-agonists.
MAOIs and TCAs
Concurrent administration may potentiate the vascular effects of salbutamol, increasing the risk of cardiovascular adverse effects.
Beta-blockers (e.g., Propranolol)
May antagonize the bronchodilatory effect of salbutamol and can cause severe bronchospasm in asthmatic patients.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include tachycardia, tremors, palpitations, hyperglycemia, hypokalemia, and lactic acidosis. Treatment is symptomatic and supportive; cardiovascular monitoring and potassium level monitoring are important.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Salbutamol is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to salbutamol or any component of the formulation
- Threatened abortion (oral salbutamol preparations are contraindicated)
Drug Interactions
Digoxin
May decrease serum digoxin levels.
Diuretics
May cause ECG changes and/or hypokalemia, especially with high doses of beta-agonists.
MAOIs and TCAs
Concurrent administration may potentiate the vascular effects of salbutamol, increasing the risk of cardiovascular adverse effects.
Beta-blockers (e.g., Propranolol)
May antagonize the bronchodilatory effect of salbutamol and can cause severe bronchospasm in asthmatic patients.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include tachycardia, tremors, palpitations, hyperglycemia, hypokalemia, and lactic acidosis. Treatment is symptomatic and supportive; cardiovascular monitoring and potassium level monitoring are important.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Salbutamol is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies worldwide
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of salbutamol in managing asthma and COPD symptoms. It is a well-established medication with extensive clinical data.
Lab Monitoring
- Serum potassium levels (especially in severe asthma or with concomitant drugs)
- Blood glucose levels (in diabetic patients)
Doctor Notes
- Emphasize proper inhaler technique if prescribing with an MDI.
- Warn patients about rebound bronchospasm if discontinuing abruptly.
- Assess for cardiovascular comorbidities before prescribing, especially in elderly patients.
Patient Guidelines
- Do not exceed the prescribed dose.
- Seek immediate medical attention if breathing difficulties worsen or do not improve after using the medication.
- Inform your doctor about all other medications you are taking.
- Carry your medication with you at all times if you have asthma or COPD.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause tremor or dizziness, which could affect the ability to drive or operate machinery. Patients should be advised to exercise caution.
Lifestyle Advice
- Avoid smoking and exposure to secondhand smoke.
- Practice breathing exercises as advised by your doctor.
- Maintain a healthy weight and diet.
- Identify and avoid asthma triggers.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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