Sarcet
Generic Name
Sarcet 10 mg Tablet
Manufacturer
Zydus Cadila
Country
India
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sarcet 10 mg tablet | ৳ 2.80 | ৳ 28.00 |
Description
Overview of the medicine
Sarcet 10 mg Tablet contains Saroglitazar, a dual PPAR alpha/gamma agonist used in the management of diabetic dyslipidemia, Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) in patients with type 2 diabetes mellitus or dyslipidemia.
Uses & Indications
Dosage
Adults
10 mg once daily, preferably before the first meal.
Elderly
No specific dose adjustment required, but caution is advised.
Renal_impairment
No dose adjustment required for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Take orally, once daily, preferably before breakfast. Swallow the tablet whole with water; do not crush, chew, or break.
Mechanism of Action
Saroglitazar acts as a dual agonist of Peroxisome Proliferator-Activated Receptors (PPAR) alpha and gamma. Activation of PPAR-alpha improves lipid metabolism by reducing triglycerides and increasing HDL cholesterol. Activation of PPAR-gamma improves insulin sensitivity and helps control blood glucose levels. This dual action contributes to its beneficial effects on both lipid and glucose metabolism.
Pharmacokinetics
Onset
Clinical effects on lipid parameters typically seen within weeks; glucose effects may take longer.
Excretion
Mainly excreted via feces, with a minor portion through urine.
Half life
Approximately 20-25 hours.
Absorption
Well absorbed orally. Peak plasma concentration (Tmax) is reached in about 1-3 hours.
Metabolism
Primarily metabolized by oxidation and glucuronidation.
Side Effects
Contraindications
- •Hypersensitivity to Saroglitazar or any excipients
- •Severe hepatic impairment
- •Pregnant or lactating women
Drug Interactions
CYP450 inhibitors/inducers
Potential for altered Saroglitazar levels, though not a major substrate.
Other anti-diabetic medications
Additive effects on glucose lowering; monitor blood glucose carefully.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be taken. There is no specific antidote.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to lack of sufficient data and potential risks. Advise women of childbearing potential to use effective contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Primarily available in India
Approval Status
Approved in India by DCGI
Patent Status
Patented (Zydus Cadila)
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Global Brand Names
International brand names for this medicine
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