sb-azit
Generic Name
Azithromycin
Manufacturer
A local pharmaceutical company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sb azit 500 mg tablet | ৳ 35.00 | N/A |
Description
Overview of the medicine
Azithromycin is a broad-spectrum macrolide antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
For most infections, 500 mg once daily for 3 days, or 500 mg as a single dose on Day 1, followed by 250 mg once daily on Days 2-5.
Elderly
No dosage adjustment is required for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment necessary for mild to moderate renal impairment (creatinine clearance >10-80 mL/min). Use with caution in severe renal impairment.
How to Take
Take orally, with or without food. Taking with food may help reduce gastrointestinal upset.
Mechanism of Action
Azithromycin binds to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting bacterial protein synthesis.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 2-3 hours.
Excretion
Primarily excreted unchanged in bile; a small amount is excreted in urine.
Half life
Terminal elimination half-life is 68 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.
Metabolism
Undergoes limited hepatic metabolism; extensively distributed into tissues.
Side Effects
Contraindications
- Known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased serum digoxin levels.
Antacids
Reduced peak plasma concentrations of azithromycin.
Warfarin
Increased anticoagulant effect.
Nelfinavir
Increased azithromycin concentrations.
Ciclosporin
Increased ciclosporin levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Azithromycin is excreted in breast milk; use with caution in nursing mothers after consulting a physician.
Side Effects
Contraindications
- Known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased serum digoxin levels.
Antacids
Reduced peak plasma concentrations of azithromycin.
Warfarin
Increased anticoagulant effect.
Nelfinavir
Increased azithromycin concentrations.
Ciclosporin
Increased ciclosporin levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Azithromycin is excreted in breast milk; use with caution in nursing mothers after consulting a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated azithromycin's efficacy and safety across various bacterial infections.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment or prolonged therapy)
- Renal function tests (in patients with severe renal impairment)
- Electrocardiogram (ECG) for QTc prolongation (in patients at risk)
Doctor Notes
- Counsel patients on the importance of completing the full course of therapy.
- Be aware of the potential for QTc prolongation, especially in patients with pre-existing cardiac conditions or those on other QTc-prolonging drugs.
- Advise patients to seek immediate medical attention if signs of severe allergic reaction or severe diarrhea occur.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Do not share this medication with others.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose.
Driving Precautions
Generally safe, but if dizziness or visual disturbances occur, avoid driving or operating heavy machinery.
Lifestyle Advice
- Stay well-hydrated during the course of treatment.
- Avoid alcohol if experiencing gastrointestinal upset.
- Monitor for signs of severe allergic reactions.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.