Administer orally once daily in the morning, with or without food. Swallow the tablet whole with liquid; do not crush or chew.

Selectively blocks beta-1 adrenergic receptors in the heart, leading to decreased heart rate, reduced myocardial contractility, and lower blood pressure. It also inhibits renin release from the kidneys.

• •Acute heart failure or decompensated heart failure requiring intravenous inotropic therapy
• •Cardiogenic shock
• •Second or third degree AV block (without pacemaker)
• •Sick sinus syndrome (without pacemaker)
• •Severe bradycardia (<50 bpm)
• •Severe bronchial asthma or severe chronic obstructive pulmonary disease
• •Late stages of peripheral arterial occlusive disease or Raynaud's syndrome
• •Metabolic acidosis

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Symptoms include severe bradycardia, hypotension, bronchospasm, acute cardiac insufficiency, and hypoglycemia. Management involves symptomatic and supportive therapy, including atropine for bradycardia, glucagon, and vasopressors for hypotension.

Pregnancy Category C. Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Bisoprolol is excreted in breast milk; caution advised during lactation and monitor the infant for beta-blockade symptoms.