sb-glic
Generic Name
Gliclazide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sb glic 80 mg tablet | ৳ 7.00 | N/A |
Description
Overview of the medicine
Gliclazide 80 mg tablet is an oral antidiabetic medicine used to control high blood sugar levels in adults with type 2 diabetes mellitus, especially when diet and exercise alone are not enough. It belongs to the sulfonylurea class of drugs.
Uses & Indications
Dosage
Adults
Initial dose: 40-80 mg once daily, preferably with breakfast. The dose can be increased gradually up to a maximum of 320 mg daily, usually given in two divided doses for doses above 160 mg.
Elderly
Similar to adult dosage, but titration should be done carefully, starting with a lower dose to avoid hypoglycemia.
Renal_impairment
Generally, no dose adjustment is required for mild to moderate renal impairment (creatinine clearance > 30 mL/min). Close monitoring is recommended. Avoid in severe renal impairment.
How to Take
Administer orally, usually once daily with breakfast. For higher doses (above 160 mg), it may be divided into two doses. Swallow the tablet whole with water; do not chew or crush.
Mechanism of Action
Gliclazide works primarily by stimulating insulin secretion from the pancreatic beta cells. It binds to a specific receptor on the beta-cell membrane, leading to the closure of ATP-sensitive potassium channels, membrane depolarization, and opening of calcium channels. The influx of calcium promotes the exocytosis of insulin.
Pharmacokinetics
Onset
Within 1-2 hours.
Excretion
Primarily excreted in the urine (less than 1% as unchanged drug), with a small amount excreted in the feces.
Half life
Approximately 8-20 hours.
Absorption
Well absorbed from the GI tract. Peak plasma concentrations are reached within 2-6 hours.
Metabolism
Extensively metabolized in the liver by CYP2C9, primarily to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Gliclazide or other sulfonylureas
- Type 1 diabetes mellitus
- Diabetic ketoacidosis, diabetic pre-coma and coma
- Severe renal or hepatic impairment
- Concomitant treatment with miconazole (systemic route)
Drug Interactions
Miconazole (systemic route)
Potentiates the hypoglycemic effect, potentially leading to severe hypoglycemia.
Phenylbutazone, other NSAIDs, salicylates
May enhance the hypoglycemic effect.
Beta-blockers, ACE inhibitors, fluconazole, H2-receptor antagonists
May increase the hypoglycemic effect. Beta-blockers can also mask symptoms of hypoglycemia.
Corticosteroids, danazol, chlorpromazine, loop diuretics, oral contraceptives
May reduce the hypoglycemic effect, potentially leading to hyperglycemia.
Storage
Store in a cool and dry place, below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose of Gliclazide can lead to severe hypoglycemia, which may present with symptoms like sweating, tremor, hunger, confusion, and unconsciousness. Management involves immediate administration of glucose (oral or intravenous) and close monitoring of blood glucose levels for at least 24-48 hours.
Pregnancy & Lactation
Gliclazide is not recommended during pregnancy. Insulin therapy is preferred for controlling diabetes in pregnant women. It is unknown whether Gliclazide is excreted in breast milk, so it should be avoided during lactation.
Side Effects
Contraindications
- Hypersensitivity to Gliclazide or other sulfonylureas
- Type 1 diabetes mellitus
- Diabetic ketoacidosis, diabetic pre-coma and coma
- Severe renal or hepatic impairment
- Concomitant treatment with miconazole (systemic route)
Drug Interactions
Miconazole (systemic route)
Potentiates the hypoglycemic effect, potentially leading to severe hypoglycemia.
Phenylbutazone, other NSAIDs, salicylates
May enhance the hypoglycemic effect.
Beta-blockers, ACE inhibitors, fluconazole, H2-receptor antagonists
May increase the hypoglycemic effect. Beta-blockers can also mask symptoms of hypoglycemia.
Corticosteroids, danazol, chlorpromazine, loop diuretics, oral contraceptives
May reduce the hypoglycemic effect, potentially leading to hyperglycemia.
Storage
Store in a cool and dry place, below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose of Gliclazide can lead to severe hypoglycemia, which may present with symptoms like sweating, tremor, hunger, confusion, and unconsciousness. Management involves immediate administration of glucose (oral or intravenous) and close monitoring of blood glucose levels for at least 24-48 hours.
Pregnancy & Lactation
Gliclazide is not recommended during pregnancy. Insulin therapy is preferred for controlling diabetes in pregnant women. It is unknown whether Gliclazide is excreted in breast milk, so it should be avoided during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Generic (Off-patent)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Gliclazide in the management of type 2 diabetes mellitus, showing significant reduction in HbA1c and beneficial effects on microvascular complications (e.g., ADVANCE trial).
Lab Monitoring
- Blood glucose levels (fasting and postprandial)
- HbA1c (Glycated Hemoglobin) every 3-6 months
- Renal function tests (e.g., serum creatinine, eGFR)
- Liver function tests (e.g., ALT, AST)
Doctor Notes
- Emphasize patient education on hypoglycemia symptoms and management.
- Advise patients on lifestyle modifications (diet, exercise).
- Monitor renal and hepatic function periodically.
- Consider Gliclazide MR for once-daily dosing convenience and potentially reduced hypoglycemia risk compared to immediate release formulations.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor, usually with your first meal of the day.
- Do not skip meals and maintain a regular eating pattern to avoid hypoglycemia.
- Be aware of the symptoms of hypoglycemia (e.g., sweating, trembling, dizziness) and carry a source of sugar (e.g., candy, juice) with you.
- Regularly monitor your blood sugar levels as advised by your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Gliclazide can cause hypoglycemia, which may impair your ability to concentrate and react. Patients should be advised to take precautions when driving or operating machinery, especially at the beginning of treatment or if doses are increased. Be aware of hypoglycemia symptoms.
Lifestyle Advice
- Follow a healthy diet plan recommended by your doctor or dietitian.
- Engage in regular physical activity as advised.
- Maintain a healthy body weight.
- Avoid excessive alcohol consumption.
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Global Brand Names
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