sb-metlina
Generic Name
Sitagliptin
Manufacturer
Reputable Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sb metlina 25 mg tablet | ৳ 12.00 | N/A |
Description
Overview of the medicine
Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor indicated for the treatment of type 2 diabetes mellitus to improve glycemic control.
Uses & Indications
Dosage
Adults
The usual recommended dose is 100 mg once daily. For 'sb-metlina-25-mg-tablet', it may be used in specific patient populations or as part of a dose titration.
Elderly
No dosage adjustment is necessary based on age alone. Dosage adjustment may be required based on renal function.
Renal_impairment
For patients with moderate renal impairment (CrCl ≥30 to <45 mL/min), the dose is 50 mg once daily. For patients with severe renal impairment (CrCl <30 mL/min) or end-stage renal disease requiring dialysis, the dose is 25 mg once daily. 'sb-metlina-25-mg-tablet' is particularly suitable for these patients.
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Sitagliptin selectively inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), which is responsible for inactivating the incretin hormones GLP-1 and GIP. By inhibiting DPP-4, Sitagliptin increases the levels of active incretin hormones, leading to enhanced glucose-dependent insulin secretion and suppressed glucagon secretion from the pancreas, thereby lowering blood glucose levels.
Pharmacokinetics
Onset
Within hours of administration.
Excretion
Primarily renal excretion (79% as unchanged drug); fecal excretion accounts for about 13%.
Half life
Approximately 12.4 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in 1 to 4 hours. Absolute bioavailability is approximately 87%.
Metabolism
Limited metabolism, primarily by CYP3A4, with a minor contribution from CYP2C8. Approximately 79% is excreted unchanged in urine.
Side Effects
Contraindications
- Hypersensitivity to Sitagliptin or any component of the formulation.
- History of serious hypersensitivity reaction to a DPP-4 inhibitor.
Drug Interactions
Digoxin
Sitagliptin may cause a minor increase in digoxin plasma concentrations. Monitoring digoxin levels is recommended.
ACE Inhibitors
Increased risk of angioedema when co-administered with ACE inhibitors.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment should be initiated. Sitagliptin is modestly dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is not known whether Sitagliptin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Sitagliptin or any component of the formulation.
- History of serious hypersensitivity reaction to a DPP-4 inhibitor.
Drug Interactions
Digoxin
Sitagliptin may cause a minor increase in digoxin plasma concentrations. Monitoring digoxin levels is recommended.
ACE Inhibitors
Increased risk of angioedema when co-administered with ACE inhibitors.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment should be initiated. Sitagliptin is modestly dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is not known whether Sitagliptin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Patent expired for generic versions
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of Sitagliptin in improving glycemic control in patients with type 2 diabetes mellitus, both as monotherapy and in combination with other antidiabetic agents.
Lab Monitoring
- Monitor renal function periodically, especially in patients with impaired renal function.
- Monitor HbA1c and blood glucose levels regularly to assess glycemic control.
Doctor Notes
- Counsel patients on proper administration and potential side effects.
- Emphasize the importance of diet and exercise in diabetes management.
- Adjust dose for renal impairment; this 25mg strength is crucial for severe renal dysfunction.
- Monitor for signs of pancreatitis or allergic reactions.
Patient Guidelines
- Take your medicine exactly as prescribed by your doctor.
- Inform your doctor about all other medicines, supplements, or herbal products you are taking.
- Report any symptoms of pancreatitis (severe abdominal pain, nausea, vomiting) immediately to your doctor.
- Be aware of symptoms of hypoglycemia, especially if you are taking a sulfonylurea or insulin concurrently.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Sitagliptin is not known to impair the ability to drive or operate machinery. However, if used in combination with a sulfonylurea or insulin, the risk of hypoglycemia may increase, which could affect driving ability.
Lifestyle Advice
- Maintain a balanced diet and regular exercise regimen.
- Monitor your blood glucose levels as advised by your healthcare provider.
- Maintain a healthy weight.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.