Seberb
Generic Name
Seberb 250 mg Tablet
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| seberb 250 mg tablet | ৳ 250.00 | ৳ 2,500.00 |
Description
Overview of the medicine
Seberb 250 mg Tablet is a broad-spectrum antibiotic effective against a wide range of bacterial infections, including those affecting the respiratory tract, urinary tract, skin, and soft tissues. It works by inhibiting bacterial protein synthesis.
Uses & Indications
Dosage
Adults
250 mg to 500 mg orally twice daily, depending on the severity and type of infection. Treatment duration typically 7-10 days.
Elderly
No specific dose adjustment required for elderly patients with normal renal function. Monitor renal function closely.
Renal_impairment
For creatinine clearance <30 mL/min, reduce dose to 250 mg once daily or as advised by physician. Not recommended for severe renal failure.
How to Take
Take the tablet orally with a glass of water, with or without food. Complete the full course of treatment as prescribed, even if symptoms improve.
Mechanism of Action
Seberb acts by selectively binding to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting protein synthesis and consequently bacterial growth. This leads to a bacteriostatic effect.
Pharmacokinetics
Onset
Clinical effects typically observed within 1-2 hours.
Excretion
Mainly excreted unchanged in urine (60-70%) and some via bile.
Half life
Elimination half-life ranges from 8 to 12 hours.
Absorption
Rapidly absorbed after oral administration, bioavailability approximately 80%. Peak plasma concentrations reached within 1-2 hours.
Metabolism
Undergoes minor hepatic metabolism, primarily excreted as unchanged drug.
Side Effects
Contraindications
- •Hypersensitivity to Seberb or any macrolide antibiotics
- •Severe hepatic dysfunction
- •Concurrent use with drugs known to prolong QT interval
Drug Interactions
Warfarin
May increase anticoagulant effect of warfarin, requiring INR monitoring.
Antacids (containing aluminum or magnesium)
May decrease absorption of Seberb; administer at least 2 hours apart.
QT-prolonging drugs (e.g., Amiodarone, Cisapride)
Increased risk of QT prolongation; concurrent use is contraindicated.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management is primarily symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during lactation. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Patent protected (expires 2030)
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Global Brand Names
International brand names for this medicine
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