Seclotil
Generic Name
Esomeprazole 40 mg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| seclotil 40 mg capsule | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Seclotil 40 mg Capsule contains Esomeprazole, a proton pump inhibitor, used to reduce stomach acid production. It is prescribed for conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. Erosive Esophagitis: 40 mg once daily for 4-8 weeks. Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted based on patient response.
Elderly
No dose adjustment required for elderly patients based on age alone.
Renal_impairment
No dose adjustment required for patients with renal impairment.
How to Take
Seclotil 40 mg capsule should be swallowed whole with water, at least one hour before a meal. Do not chew or crush the capsule.
Mechanism of Action
Esomeprazole irreversibly blocks the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells, thereby inhibiting the final step of acid secretion. This leads to a dose-dependent inhibition of both basal and stimulated gastric acid secretion.
Pharmacokinetics
Onset
Acid secretion inhibition begins within 1 hour.
Excretion
Metabolites are primarily excreted in the urine (about 80%) and feces (about 20%).
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; absolute bioavailability is approximately 64% after a single 40 mg dose, increasing to 89% after repeated once-daily administration.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system, mainly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation
- Concomitant use with nelfinavir (an antiretroviral drug)
Drug Interactions
Warfarin
Increased INR and prothrombin time have been reported, requiring monitoring.
Clopidogrel
Potential reduction in antiplatelet activity of clopidogrel due to CYP2C19 inhibition, although clinical significance is debated.
Methotrexate
Possible increase in methotrexate levels, especially with high doses.
Nelfinavir, Atazanavir
Esomeprazole decreases plasma concentrations of these antiretrovirals, reducing their efficacy. Concomitant use is contraindicated with nelfinavir and not recommended with atazanavir.
Diazepam, Citalopram, Imipramine, Phenytoin
Esomeprazole may increase plasma levels of drugs metabolized by CYP2C19.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include gastrointestinal disturbances and weakness. Treatment is symptomatic and supportive. Esomeprazole is extensively protein bound and is therefore not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is unknown if esomeprazole is excreted in human milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved
Patent Status
Patent expired, available as generic
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Esomeprazole's efficacy in healing erosive esophagitis and reducing GERD symptoms, showing superior acid suppression compared to some other PPIs.
Lab Monitoring
- Monitor liver function tests periodically in patients with severe hepatic impairment.
- Check magnesium levels in patients on prolonged therapy (e.g., >3 months) or taking other magnesium-lowering drugs.
Doctor Notes
- Advise patients on appropriate administration (before meals, swallow whole).
- Counsel on potential long-term risks with PPIs and the need for periodic review.
- Consider magnesium supplementation for patients on prolonged PPI therapy, especially if diuretics are co-administered.
Patient Guidelines
- Take the capsule whole; do not crush or chew.
- Take at least one hour before a meal.
- Inform your doctor about all other medications you are taking.
- Report any unusual or severe side effects to your doctor immediately.
- Do not stop the medication suddenly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Esomeprazole generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or blurred vision, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid spicy, fatty, and acidic foods that can trigger acid reflux.
- Elevate the head of your bed to reduce nighttime reflux.
- Avoid lying down immediately after meals.
- Maintain a healthy weight.
- Quit smoking and limit alcohol intake.
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Global Brand Names
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