Sedno
Generic Name
Zopiclone 5 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sedno 5 mg tablet | ৳ 2.52 | ৳ 25.20 |
Description
Overview of the medicine
Sedno 5 mg Tablet contains Zopiclone, a non-benzodiazepine hypnotic used for the short-term treatment of insomnia.
Uses & Indications
Dosage
Adults
The usual adult dose is 7.5 mg orally at bedtime. For Sedno 5 mg, it may be prescribed as an initial dose or for sensitive patients.
Elderly
Start with a lower dose of 3.75 mg; maximum 5 mg, taken orally at bedtime.
Renal_impairment
Start with a lower dose of 3.75 mg orally at bedtime. Dosage should be adjusted based on clinical response and tolerability.
How to Take
Take orally, immediately before bedtime. Do not take with food if faster onset is desired, although food does not significantly alter total absorption.
Mechanism of Action
Zopiclone potentiates the effects of GABA by binding to GABA-A receptors, leading to an increase in chloride ion influx and subsequent neuronal hyperpolarization, which enhances inhibitory neurotransmission in the central nervous system, thus promoting sleep.
Pharmacokinetics
Onset
Approximately 30 minutes after oral administration.
Excretion
Mainly excreted in urine (about 80%) and feces (about 16%), predominantly as metabolites.
Half life
The elimination half-life is 3.5 to 6.5 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1 to 2 hours. Bioavailability is approximately 80%.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4 and CYP2C8, to two main metabolites: an active N-desmethylzopiclone and an inactive zopiclone-N-oxide.
Side Effects
Contraindications
- •Hypersensitivity to zopiclone or any excipient
- •Severe respiratory insufficiency
- •Severe hepatic insufficiency
- •Sleep apnea syndrome
- •Myasthenia gravis
Drug Interactions
CNS depressants (e.g., alcohol, benzodiazepines, opioids)
Increased sedative effect and central nervous system depression.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir)
May increase zopiclone plasma levels, potentially leading to increased sedative effects.
CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenobarbital)
May decrease zopiclone plasma levels, potentially reducing its hypnotic effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, lethargy, ataxia, hypotonia, hypotension, and respiratory depression. Treatment is supportive and symptomatic; gastric lavage may be considered if ingestion was recent. Flumazenil may be used in severe cases but is not routinely recommended for non-benzodiazepines.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the third trimester due to risk of neonatal withdrawal symptoms. Zopiclone is excreted in breast milk; therefore, use during lactation should be avoided.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months, usually stated on the packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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