Seebrox
Generic Name
Levocetirizine
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| seebrox 15 mg syrup | ৳ 40.00 | N/A |
Description
Overview of the medicine
Seebrox 15 mg syrup contains Levocetirizine, a non-sedating antihistamine. It is used to relieve symptoms associated with various allergic conditions such as allergic rhinitis and chronic urticaria.
Uses & Indications
Dosage
Adults
The usual recommended dose of Levocetirizine for adults is 5 mg once daily. For Seebrox 15 mg syrup, a doctor's guidance is essential to determine the appropriate volume corresponding to a 5 mg or other suitable therapeutic dose, as 15 mg is typically higher than a standard single adult dose.
Elderly
No dosage adjustment is generally required in elderly patients with normal renal function. For those with impaired renal function, dosage should be adjusted based on creatinine clearance.
Renal_impairment
Dosage should be adjusted based on creatinine clearance. For patients with mild renal impairment (CrCl 50-79 mL/min), 5 mg once daily. For moderate impairment (CrCl 30-49 mL/min), 5 mg every other day. For severe impairment (CrCl <30 mL/min), 5 mg twice weekly. Not recommended for end-stage renal disease patients.
How to Take
Seebrox syrup should be taken orally, with or without food. It can be taken in the evening to mitigate potential drowsiness.
Mechanism of Action
Levocetirizine is a potent and selective antagonist of peripheral H1-receptors. It blocks the effects of histamine, a substance naturally produced by the body during an allergic reaction, thereby reducing allergic symptoms like sneezing, runny nose, watery eyes, and itching.
Pharmacokinetics
Onset
Onset of action typically occurs within 1 hour.
Excretion
Primarily excreted unchanged in the urine (approximately 85.4% of the dose) and to a lesser extent in feces (12.9%).
Half life
Plasma elimination half-life is approximately 7 to 10 hours.
Absorption
Rapidly absorbed after oral administration, reaching peak plasma concentrations in about 0.9 to 1 hour.
Metabolism
Less than 14% of the dose is metabolized in humans by O-dealkylation, with negligible cytochrome P450 involvement.
Side Effects
Contraindications
- Hypersensitivity to levocetirizine, cetirizine, or any other piperazine derivatives, or to any of the excipients.
- Patients with severe renal impairment (creatinine clearance less than 10 mL/min) or end-stage renal disease.
- Patients undergoing hemodialysis.
Drug Interactions
Ritonavir
May increase the plasma levels of levocetirizine, although not clinically significant.
Central Nervous System Depressants
Concurrent use with alcohol or other CNS depressants (e.g., sedatives, hypnotics, tranquilizers) may cause additional reductions in alertness and impair CNS performance.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness in adults and initial agitation and restlessness followed by drowsiness in children. Treatment is symptomatic and supportive. There is no specific antidote for levocetirizine. Gastric lavage or activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Levocetirizine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to levocetirizine, cetirizine, or any other piperazine derivatives, or to any of the excipients.
- Patients with severe renal impairment (creatinine clearance less than 10 mL/min) or end-stage renal disease.
- Patients undergoing hemodialysis.
Drug Interactions
Ritonavir
May increase the plasma levels of levocetirizine, although not clinically significant.
Central Nervous System Depressants
Concurrent use with alcohol or other CNS depressants (e.g., sedatives, hypnotics, tranquilizers) may cause additional reductions in alertness and impair CNS performance.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness in adults and initial agitation and restlessness followed by drowsiness in children. Treatment is symptomatic and supportive. There is no specific antidote for levocetirizine. Gastric lavage or activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Levocetirizine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, when stored as recommended.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have established the efficacy and safety of levocetirizine for allergic rhinitis and chronic idiopathic urticaria. Ongoing research may explore new indications or formulations.
Lab Monitoring
- Regular monitoring of renal function may be advisable for patients with existing renal impairment or for prolonged use.
Doctor Notes
- Emphasize the importance of patient education regarding potential drowsiness, especially when starting treatment.
- Advise patients with renal impairment on appropriate dosage adjustments.
- Counsel patients on avoiding alcohol and other CNS depressants during treatment.
Patient Guidelines
- Do not exceed the recommended dose without consulting a doctor.
- Avoid alcohol while taking this medicine as it may increase drowsiness.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Levocetirizine may cause drowsiness or dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how this medicine affects them.
Lifestyle Advice
- Maintain good hydration.
- Avoid known allergens to reduce the frequency and severity of allergic reactions.
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