seemacheph
Generic Name
Cefixime 125 mg Suspension
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| seemacheph 125 mg suspension | ৳ 77.00 | N/A |
Description
Overview of the medicine
Seemacheph 125 mg Suspension is an oral third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections in children, including respiratory tract infections, urinary tract infections, otitis media, and pharyngitis.
Uses & Indications
Dosage
Adults
Adults: 400 mg once daily or 200 mg every 12 hours, for 7-14 days depending on the infection. (Suspension generally used for children).
Elderly
Elderly patients with normal renal function can receive the usual adult dose. Dose adjustment needed for renal impairment.
Renal_impairment
For creatinine clearance 21-60 ml/min: 300 mg daily. For creatinine clearance < 20 ml/min: 200 mg daily.
How to Take
Administer orally with or without food. Shake the suspension well before each use. Use a calibrated measuring spoon or cup for accurate dosing.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-6 hours.
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. Some excretion also occurs via bile.
Half life
Plasma half-life averages 3 to 4 hours.
Absorption
Approximately 40-50% orally absorbed. Absorption is not significantly altered by the presence of food.
Metabolism
Not significantly metabolized in the liver.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin.
Drug Interactions
Nifedipine
May increase cefixime peak plasma concentration and AUC.
Carbamazepine
Elevated carbamazepine levels may occur, requiring monitoring.
Oral Anticoagulants (e.g., Warfarin)
Increased prothrombin time and INR, potentially leading to increased bleeding risk.
Storage
Store the dry powder below 30°C in a dry place, away from light and moisture. Keep the reconstituted suspension refrigerated (2-8°C) and discard after 7-14 days.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be symptomatic and supportive. Hemodialysis or peritoneal dialysis do not remove cefixime from the circulation to a significant extent.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin.
Drug Interactions
Nifedipine
May increase cefixime peak plasma concentration and AUC.
Carbamazepine
Elevated carbamazepine levels may occur, requiring monitoring.
Oral Anticoagulants (e.g., Warfarin)
Increased prothrombin time and INR, potentially leading to increased bleeding risk.
Storage
Store the dry powder below 30°C in a dry place, away from light and moisture. Keep the reconstituted suspension refrigerated (2-8°C) and discard after 7-14 days.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be symptomatic and supportive. Hemodialysis or peritoneal dialysis do not remove cefixime from the circulation to a significant extent.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: Typically 24-36 months. Reconstituted suspension: 7-14 days when refrigerated (2-8°C).
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved (Generic)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections in both pediatric and adult populations.
Lab Monitoring
- Complete Blood Count (CBC) for prolonged therapy.
- Renal function tests (e.g., creatinine clearance) in patients with pre-existing renal impairment or during prolonged high-dose therapy.
- Liver function tests if clinically indicated.
Doctor Notes
- Confirm bacterial etiology before prescribing.
- Educate parents/caregivers on the importance of completing the full course.
- Monitor for signs of hypersensitivity reactions and C. difficile infection.
Patient Guidelines
- Complete the entire prescribed course of medication, even if symptoms improve.
- Do not save medication for future use or share it with others.
- Shake the suspension well before each use and measure with the provided device.
- Report any severe or persistent diarrhea to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, if you experience dizziness, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Ensure adequate hydration, especially if experiencing diarrhea.
- Avoid self-medication with antibiotics.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in seemacheph Brand
Other medicines available under the same brand name
