Seematrin
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| seematrin 200 mg suspension | ৳ 24.00 | N/A |
Description
Overview of the medicine
Seematrin 200 mg Suspension is a macrolide antibiotic used to treat various bacterial infections in children.
Uses & Indications
Dosage
Adults
Not typically used for adults at 200 mg suspension strength. Adult doses usually start from 500 mg.
Elderly
No specific dose adjustment is required unless severe renal or hepatic impairment.
Children
For children 6 months and older: 10 mg/kg once daily for 3 days, OR 10 mg/kg on Day 1 followed by 5 mg/kg on Days 2-5.
Renal_impairment
Mild to moderate renal impairment does not require dose adjustment. Use with caution in severe renal impairment (CrCl < 10 ml/min).
Hepatic_impairment
Use with caution in patients with hepatic impairment, as azithromycin is primarily cleared by the liver.
How to Take
Orally, once daily, with or without food. Shake the bottle well before each use. Use the provided measuring spoon or cup for accurate dosing. Finish the full prescribed course.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby interfering with the translation of mRNA.
Pharmacokinetics
Onset
Peak plasma concentration typically reached within 2-3 hours.
Excretion
Primarily excreted unchanged into bile; minor renal excretion (about 6% of the dose).
Half life
Terminal elimination half-life is approximately 2-4 days due to extensive tissue uptake and slow release.
Absorption
Well absorbed orally, bioavailability is approximately 37%. Food may slightly reduce absorption.
Metabolism
Partially metabolized in the liver, primarily by N-demethylation; however, a significant portion is excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
May increase serum digoxin levels. Monitor digoxin levels if co-administered.
Warfarin
Increased anticoagulant effect reported. Monitor INR closely during co-administration.
Nelfinavir
Increased azithromycin concentration. Monitor for known azithromycin side effects.
Antacids (aluminum and magnesium-containing)
May reduce the peak plasma concentration of azithromycin. Administer azithromycin at least 1 hour before or 2 hours after antacids.
QT-prolonging drugs (e.g., amiodarone, sotalol, quinidine)
Increased risk of QT prolongation and Torsades de Pointes. Avoid concomitant use if possible.
Storage
Store the powder below 30°C, protected from light and moisture. Store the reconstituted suspension below 30°C and use within 5 days; do not refrigerate. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Gastric lavage and general supportive measures are recommended.
Pregnancy & Lactation
Pregnancy Category B. Azithromycin should be used during pregnancy only if clearly needed. It is excreted in human breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
May increase serum digoxin levels. Monitor digoxin levels if co-administered.
Warfarin
Increased anticoagulant effect reported. Monitor INR closely during co-administration.
Nelfinavir
Increased azithromycin concentration. Monitor for known azithromycin side effects.
Antacids (aluminum and magnesium-containing)
May reduce the peak plasma concentration of azithromycin. Administer azithromycin at least 1 hour before or 2 hours after antacids.
QT-prolonging drugs (e.g., amiodarone, sotalol, quinidine)
Increased risk of QT prolongation and Torsades de Pointes. Avoid concomitant use if possible.
Storage
Store the powder below 30°C, protected from light and moisture. Store the reconstituted suspension below 30°C and use within 5 days; do not refrigerate. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Gastric lavage and general supportive measures are recommended.
Pregnancy & Lactation
Pregnancy Category B. Azithromycin should be used during pregnancy only if clearly needed. It is excreted in human breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months for the powder before reconstitution. Reconstituted suspension is stable for 5 days when stored below 30°C (do not refrigerate).
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory bodies (e.g., DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Azithromycin has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various bacterial infections in both adult and pediatric populations.
Lab Monitoring
- Liver function tests (LFTs) if prolonged use or pre-existing hepatic impairment.
- Renal function tests if severe renal impairment.
- INR for patients on warfarin.
- ECG monitoring for patients at risk of QT prolongation.
Doctor Notes
- Emphasize to parents the importance of completing the full prescribed course of antibiotics, even if the child's symptoms improve.
- Advise parents on proper measurement and administration techniques for the suspension.
- Counsel about potential gastrointestinal side effects and advise taking with food if severe GI upset occurs.
- Be aware of potential drug interactions, especially with warfarin, digoxin, and QT-prolonging agents.
Patient Guidelines
- Always complete the full course of medication, even if symptoms improve, to prevent recurrence and antibiotic resistance.
- Shake the suspension well before each use to ensure even distribution of the medicine.
- Use the provided measuring device (spoon or cup) to ensure accurate dosing, especially for children.
- Report any persistent severe diarrhea, severe abdominal pain, or yellowing of the skin/eyes to your doctor immediately.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Seematrin may cause dizziness or visual disturbances in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hand hygiene to prevent the spread of infections.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea or vomiting.
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