Sefox
Generic Name
Cefixime
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sefox 100 mg capsule | ৳ 22.08 | ৳ 88.33 |
| sefox 40 mg suspension | ৳ 98.00 | N/A |
Description
Overview of the medicine
Sefox (Cefixime) is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections including those of the ear, nose, throat, lower respiratory tract, urinary tract, and uncomplicated gonorrhea.
Uses & Indications
Dosage
Adults
Adults and children over 10 years or weighing over 50 kg: 200 mg once daily or 100 mg twice daily. For severe infections or gonorrhea, dose may be increased to 400 mg once daily.
Elderly
No special dosage adjustment is required unless renal function is severely impaired.
Renal_impairment
Dosage adjustment is recommended for patients with creatinine clearance < 60 mL/min.
How to Take
Sefox capsules can be taken with or without food. To ensure complete absorption and minimize potential gastrointestinal upset, it is often recommended to take it with food. For oral suspension, shake well before use.
Mechanism of Action
Cefixime is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the final transpeptidation step of peptidoglycan synthesis, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Onset of action within a few hours of administration.
Excretion
Primarily excreted unchanged in the urine (about 50-55% of the absorbed dose) and some via bile/feces.
Half life
Plasma half-life averages 3 to 4 hours.
Absorption
Approximately 40-50% of an oral dose is absorbed, with peak plasma concentrations occurring between 2 to 6 hours.
Metabolism
Cefixime is not extensively metabolized; about 10% may be metabolized in the liver.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Carbamazepine
Elevated carbamazepine levels have been reported with concurrent cefixime administration.
Aminoglycosides
Potential for additive nephrotoxicity, especially in patients with impaired renal function.
Anticoagulants (e.g., Warfarin)
May increase prothrombin time (INR) and risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. No specific antidote exists. Supportive therapy is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Should be used during pregnancy only if clearly needed. It is not known whether cefixime is excreted in human milk. Caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Carbamazepine
Elevated carbamazepine levels have been reported with concurrent cefixime administration.
Aminoglycosides
Potential for additive nephrotoxicity, especially in patients with impaired renal function.
Anticoagulants (e.g., Warfarin)
May increase prothrombin time (INR) and risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. No specific antidote exists. Supportive therapy is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Should be used during pregnancy only if clearly needed. It is not known whether cefixime is excreted in human milk. Caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, check expiry date on pack.
Availability
Available in all pharmacies
Approval Status
Widely approved internationally and by DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of cefixime for various bacterial infections. Ongoing research may explore new indications or formulations.
Lab Monitoring
- Regular monitoring of renal function may be advised in patients with pre-existing renal impairment or during prolonged high-dose therapy.
- Monitoring of INR for patients on warfarin.
- Periodic complete blood count.
Doctor Notes
- Consider culture and susceptibility testing for resistant strains.
- Advise patients on potential for C. difficile associated diarrhea.
- Adjust dose in renal impairment.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Complete the full course of treatment, even if you feel better, to prevent recurrence and resistance.
- Do not share your medication with others.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, some individuals may experience dizziness, which could affect these activities. Caution is advised.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Drink plenty of fluids unless otherwise advised by your doctor.
- Avoid alcohol during treatment as it may exacerbate side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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