Sefril DS
Generic Name
Cefuroxime Axetil 250 mg Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sefril ds 250 mg suspension | ৳ 120.82 | N/A |
Description
Overview of the medicine
Sefril DS 250 mg Suspension contains Cefuroxime Axetil, a broad-spectrum, second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections in children and adults. It is effective against various bacteria causing infections in the respiratory tract, urinary tract, skin, and soft tissues.
Uses & Indications
Dosage
Adults
Typical dose is 250 mg twice daily for most infections. For more severe infections or bronchitis, 500 mg twice daily. For uncomplicated gonorrhea, a single dose of 1000 mg.
Elderly
Similar to adult dosage; however, renal function should be assessed, and dosage adjusted if necessary.
Children
10 mg/kg twice daily for most infections (maximum 250 mg twice daily). For otitis media, 15 mg/kg twice daily (maximum 250 mg twice daily). Duration typically 5-10 days.
Renal_impairment
Dose adjustment is required based on creatinine clearance (e.g., reduce frequency or dose for CrCl < 30 mL/min).
How to Take
Sefril DS 250 mg Suspension should be taken orally, preferably with food, to enhance absorption and reduce gastrointestinal upset. Shake the bottle well before each use. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Cefuroxime Axetil works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, which prevents the cross-linking of peptidoglycan units, ultimately leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved approximately 2-3 hours after oral administration with food.
Excretion
Cefuroxime is excreted unchanged, primarily by the kidneys via glomerular filtration and tubular secretion. Approximately 50% of the dose is excreted in the urine within 12 hours.
Half life
The plasma half-life is approximately 1.2 to 1.5 hours.
Absorption
Cefuroxime axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed by esterases to cefuroxime. Absorption is enhanced when taken with food.
Metabolism
Cefuroxime axetil is rapidly hydrolyzed in the intestinal mucosa and blood to release cefuroxime into the circulation. It is not significantly metabolized in the liver.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime axetil, any other cephalosporin antibiotics, or any of the excipients.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agents (e.g., penicillins, monobactams and carbapenems).
Drug Interactions
Warfarin
Although no significant interaction has been demonstrated, caution is advised when co-administering with anticoagulants due to potential for increased INR.
Probenecid
Concomitant administration of probenecid increases the area under the serum concentration versus time curve (AUC) of cefuroxime by about 50%, prolonging its half-life.
Oral Contraceptives
Cefuroxime may affect gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives.
Antacids, H2-blockers, PPIs
Drugs that reduce gastric acidity can lead to a lower bioavailability of cefuroxime axetil. Therefore, they should not be co-administered.
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard any unused portion after 7-10 days.
Overdose
Overdose of cephalosporins can cause cerebral irritation leading to convulsions. Management is symptomatic and supportive. Hemodialysis and peritoneal dialysis may be helpful in removing cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if clearly needed. Cefuroxime is excreted in breast milk in small amounts; caution should be exercised when administering to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime axetil, any other cephalosporin antibiotics, or any of the excipients.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agents (e.g., penicillins, monobactams and carbapenems).
Drug Interactions
Warfarin
Although no significant interaction has been demonstrated, caution is advised when co-administering with anticoagulants due to potential for increased INR.
Probenecid
Concomitant administration of probenecid increases the area under the serum concentration versus time curve (AUC) of cefuroxime by about 50%, prolonging its half-life.
Oral Contraceptives
Cefuroxime may affect gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives.
Antacids, H2-blockers, PPIs
Drugs that reduce gastric acidity can lead to a lower bioavailability of cefuroxime axetil. Therefore, they should not be co-administered.
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard any unused portion after 7-10 days.
Overdose
Overdose of cephalosporins can cause cerebral irritation leading to convulsions. Management is symptomatic and supportive. Hemodialysis and peritoneal dialysis may be helpful in removing cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if clearly needed. Cefuroxime is excreted in breast milk in small amounts; caution should be exercised when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unopened: 24-36 months. Reconstituted suspension: 7-10 days when stored in a refrigerator (2-8°C).
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefuroxime axetil has undergone extensive clinical trials demonstrating its efficacy and safety in treating various bacterial infections in both adult and pediatric populations. Studies have confirmed its effectiveness in respiratory, urinary, and skin infections.
Lab Monitoring
- Periodic assessment of renal and hepatic function is advised during prolonged therapy.
- Monitor complete blood count (CBC) in patients receiving prolonged therapy.
Doctor Notes
- Emphasize the importance of completing the full course of treatment to prevent resistance.
- Caution in patients with a history of penicillin allergy, especially severe reactions.
- Advise parents/caregivers on proper reconstitution and accurate dosing for pediatric patients.
Patient Guidelines
- Complete the full course of antibiotic treatment, even if symptoms improve, to prevent recurrence and development of resistance.
- Shake the suspension well before each use.
- Take with food to improve absorption and minimize gastrointestinal side effects.
- Use the provided measuring device for accurate dosing, do not use household spoons.
- Inform your doctor about any history of allergies, especially to penicillin or other antibiotics.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness. Patients should be warned to be cautious when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol consumption during treatment as it may exacerbate side effects.
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