Sefro
Generic Name
Cefuroxime Axetil
Manufacturer
Square Pharmaceuticals PLC.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sefro 500 mg capsule | ৳ 15.00 | ৳ 90.00 |
Description
Overview of the medicine
Cefuroxime axetil is a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
Typically 500 mg twice daily for most infections. Dosage may vary based on infection severity and type.
Elderly
Similar to adults, but dosage adjustment may be needed in case of significant renal impairment.
Renal_impairment
Dosage adjustment is required. For creatinine clearance 10-29 mL/min, 250 mg once daily. For <10 mL/min, 250 mg every 48 hours.
How to Take
Take with food to enhance absorption and minimize gastrointestinal upset. Swallow the capsule whole with water; do not chew or crush.
Mechanism of Action
It works by inhibiting bacterial cell wall synthesis, leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations are typically reached within 2-3 hours after oral administration.
Excretion
Primarily excreted unchanged by glomerular filtration and tubular secretion in the urine.
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration and hydrolyzed to active cefuroxime. Absorption is enhanced when taken with food.
Metabolism
Hydrolyzed in the intestinal mucosa and blood to release active cefuroxime. It is not significantly metabolized in the liver.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reactions to any other type of beta-lactam antibacterial agents (e.g., penicillins).
Drug Interactions
Probenecid
Concomitant use with probenecid increases cefuroxime plasma concentrations and prolongs its half-life.
Oral Anticoagulants
May potentiate the anticoagulant effect. Monitor INR/PT.
Oral Contraceptives
May reduce the efficacy of oral contraceptives. Advise using additional non-hormonal contraception.
Antacids/H2 Blockers
Drugs that reduce gastric acidity may decrease the absorption of cefuroxime axetil. Take at least 2 hours apart.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include cerebral irritation leading to convulsions. Management is supportive. Hemodialysis can reduce cefuroxime serum levels.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. Cefuroxime is excreted in small amounts in breast milk; generally considered safe, but use with caution and monitor the infant for diarrhea or candidiasis.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reactions to any other type of beta-lactam antibacterial agents (e.g., penicillins).
Drug Interactions
Probenecid
Concomitant use with probenecid increases cefuroxime plasma concentrations and prolongs its half-life.
Oral Anticoagulants
May potentiate the anticoagulant effect. Monitor INR/PT.
Oral Contraceptives
May reduce the efficacy of oral contraceptives. Advise using additional non-hormonal contraception.
Antacids/H2 Blockers
Drugs that reduce gastric acidity may decrease the absorption of cefuroxime axetil. Take at least 2 hours apart.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include cerebral irritation leading to convulsions. Management is supportive. Hemodialysis can reduce cefuroxime serum levels.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. Cefuroxime is excreted in small amounts in breast milk; generally considered safe, but use with caution and monitor the infant for diarrhea or candidiasis.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Cefuroxime axetil has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections. Ongoing post-marketing surveillance continues to monitor its profile.
Lab Monitoring
- Renal function (creatinine, BUN) should be monitored, especially in patients with pre-existing renal impairment or during prolonged high-dose therapy.
- Liver function tests (ALT, AST) if abnormalities are suspected.
- Complete Blood Count (CBC) for prolonged treatment durations.
Doctor Notes
- Emphasize the importance of completing the full antibiotic course to prevent therapeutic failure and the emergence of resistant strains.
- Advise patients to report any severe or persistent diarrhea, as it could indicate C. difficile-associated diarrhea.
- Caution about potential drug interactions, especially with oral contraceptives and antacids.
Patient Guidelines
- Take the medicine for the full prescribed duration, even if symptoms improve, to prevent recurrence and development of resistance.
- Always take with food to improve absorption and reduce stomach upset.
- Do not share this medicine with others, even if they have similar symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness. Patients should be advised to exercise caution when driving or operating machinery until they know how Sefro-500-mg-capsule affects them.
Lifestyle Advice
- Maintain good hygiene to prevent bacterial infections.
- Stay hydrated by drinking plenty of fluids.
- Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Sefro Brand
Other medicines available under the same brand name
