Selotin
Generic Name
Sertraline Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| selotin 50 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Selotin 50 mg Tablet contains Sertraline, a selective serotonin reuptake inhibitor (SSRI) used to treat various mental health conditions like depression, panic disorder, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD). It helps restore the balance of a natural substance (serotonin) in the brain.
Uses & Indications
Dosage
Adults
Initial dose is typically 50 mg once daily. May be increased up to 200 mg daily based on response and tolerability. For OCD, initial dose 50 mg daily, for panic disorder/PTSD/social anxiety, initial 25 mg daily then increased to 50 mg daily after one week.
Elderly
Lower initial doses and slower titration may be considered due to potential for increased sensitivity.
Renal_impairment
No dose adjustment is generally needed for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Take orally, once daily, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Sertraline selectively inhibits the reuptake of serotonin (5-HT) into presynaptic neurons, thereby increasing the concentration of serotonin in the synaptic cleft. This leads to enhanced serotonergic neurotransmission in the central nervous system.
Pharmacokinetics
Onset
Therapeutic effects may take 1-4 weeks to become apparent.
Excretion
Excreted in urine and feces, primarily as metabolites.
Half life
Approximately 26 hours (22-36 hours) for sertraline and 62-104 hours for its active metabolite, desmethylsertraline.
Absorption
Well absorbed after oral administration, peak plasma concentrations reached within 4.5 to 8.4 hours.
Metabolism
Extensive first-pass metabolism in the liver by multiple cytochrome P450 enzymes (mainly CYP2D6, CYP2C19, CYP2B6, CYP2C9, CYP3A4).
Side Effects
Contraindications
- Concomitant use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of discontinuing an MAOI (due to risk of serotonin syndrome)
- Concomitant use with pimozide
- Hypersensitivity to sertraline or any component of the formulation
Drug Interactions
MAOIs
Risk of serious, sometimes fatal, serotonin syndrome.
Pimozide
Increased pimozide levels and cardiotoxicity.
Warfarin
Potentiation of anticoagulant effect.
CYP2D6 metabolized drugs (e.g., tricyclic antidepressants, risperidone)
Sertraline is a moderate inhibitor of CYP2D6, potentially increasing levels of co-administered drugs.
Other serotonergic drugs (e.g., triptans, fentanyl, lithium, tramadol, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, vomiting, tachycardia, nausea, dizziness, agitation, tremor, and coma. Management is supportive and symptomatic, with maintenance of airway, breathing, and circulation. Activated charcoal and gastric lavage may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk to the fetus. Neonates exposed to SSRIs late in the third trimester have developed complications. Excreted in breast milk, use with caution during lactation; monitor infant for side effects.
Side Effects
Contraindications
- Concomitant use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of discontinuing an MAOI (due to risk of serotonin syndrome)
- Concomitant use with pimozide
- Hypersensitivity to sertraline or any component of the formulation
Drug Interactions
MAOIs
Risk of serious, sometimes fatal, serotonin syndrome.
Pimozide
Increased pimozide levels and cardiotoxicity.
Warfarin
Potentiation of anticoagulant effect.
CYP2D6 metabolized drugs (e.g., tricyclic antidepressants, risperidone)
Sertraline is a moderate inhibitor of CYP2D6, potentially increasing levels of co-administered drugs.
Other serotonergic drugs (e.g., triptans, fentanyl, lithium, tramadol, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, vomiting, tachycardia, nausea, dizziness, agitation, tremor, and coma. Management is supportive and symptomatic, with maintenance of airway, breathing, and circulation. Activated charcoal and gastric lavage may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk to the fetus. Neonates exposed to SSRIs late in the third trimester have developed complications. Excreted in breast milk, use with caution during lactation; monitor infant for side effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established sertraline's efficacy and safety in various indications, particularly depression, OCD, and panic disorder. Ongoing research includes long-term effects and use in specific populations.
Lab Monitoring
- Monitor sodium levels (especially in elderly and those on diuretics)
- Monitor liver function tests periodically
Doctor Notes
- Educate patients about the delayed onset of action and the importance of continued treatment.
- Monitor for signs of serotonin syndrome, especially when co-administered with other serotonergic agents.
- Counsel patients on the risk of suicidal ideation and the need to report any changes in mood or behavior.
Patient Guidelines
- Take consistently as prescribed by your doctor.
- Do not stop taking this medication abruptly, as it can lead to withdrawal symptoms.
- Report any worsening depression or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness, especially at the start of treatment. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Engage in regular physical activity.
- Maintain a balanced diet and adequate sleep.
- Avoid alcohol and illicit drugs.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.