Sentix
Generic Name
Zolpidem
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sentix 1 mg tablet | ৳ 6.00 | ৳ 60.00 |
| sentix 05 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Sentix (Zolpidem) is a short-acting non-benzodiazepine hypnotic indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation.
Uses & Indications
Dosage
Adults
The recommended dose for adults is 5 mg or 10 mg taken orally immediately before bedtime. The maximum daily dose is 10 mg.
Elderly
For elderly or debilitated patients, the recommended initial dose is 5 mg immediately before bedtime.
Renal_impairment
No specific dose adjustment is generally required for patients with mild to moderate renal impairment, but caution is advised.
How to Take
Take orally immediately before bedtime. Do not take with or immediately after a meal, as this may delay the onset of action. Swallow the tablet whole with water.
Mechanism of Action
Zolpidem selectively binds to the benzodiazepine-1 (omega-1) receptor subtype of the GABA-A receptor complex, enhancing GABAergic transmission and producing sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant effects.
Pharmacokinetics
Onset
Onset of action within 30 minutes.
Excretion
Excreted mainly in the urine (approximately 60%) and feces (approximately 40%) as inactive metabolites.
Half life
Elimination half-life is approximately 2-3 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 0.5-3 hours.
Metabolism
Extensively metabolized in the liver via cytochrome P450 enzymes, primarily CYP3A4, CYP2C9, and CYP2C19.
Side Effects
Contraindications
- Hypersensitivity to zolpidem or any component of the formulation
- Severe hepatic impairment
- Sleep apnea syndrome
- Myasthenia gravis
- Severe respiratory insufficiency
Drug Interactions
Alcohol
Concurrent use with alcohol can increase CNS depression and impair psychomotor performance.
CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir)
May increase zolpidem exposure and enhance its effects. Dose reduction may be necessary.
CYP3A4 Inducers (e.g., rifampicin, St. John's Wort)
May decrease zolpidem exposure and reduce its efficacy.
Other CNS Depressants (e.g., benzodiazepines, opioids, tricyclic antidepressants)
Additive CNS depressant effects.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include impaired consciousness ranging from somnolence to coma, and cardiorespiratory depression. Treatment should be symptomatic and supportive, with immediate gastric lavage if appropriate. Flumazenil may be considered as an antidote but should be administered with caution.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Zolpidem is excreted in breast milk; therefore, it is not recommended for use by nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired, generic available
Clinical Trials
Extensive clinical trials have demonstrated Zolpidem's efficacy in reducing sleep latency and improving sleep maintenance in adults with insomnia. Safety profiles have been established through numerous studies.
Lab Monitoring
- No routine laboratory monitoring is typically required. However, liver function tests may be considered in patients with severe hepatic impairment.
Doctor Notes
- Emphasize short-term use only (typically 7-10 days, max 4 weeks) to minimize risk of dependence.
- Counsel patients on potential for complex sleep behaviors and the importance of immediate discontinuation if these occur.
- Caution should be exercised in elderly patients due to increased risk of falls and CNS depression. Consider lower initial dose.
- Advise patients not to consume alcohol or other CNS depressants concurrently.
- Assess for underlying causes of insomnia before initiating zolpidem treatment.
Patient Guidelines
- Take exactly as prescribed by your doctor, usually just before going to bed.
- Do not take more than 10 mg in a 24-hour period.
- Avoid alcohol consumption while taking this medicine.
- Do not drive or operate heavy machinery after taking zolpidem.
Missed Dose Advice
If you miss a dose and it is not close to your normal wake-up time, do not take the missed dose. Simply skip it and take your next dose at the regular time. Do not take a double dose.
Driving Precautions
Zolpidem can cause drowsiness, dizziness, and impaired motor skills, which can affect your ability to drive or operate machinery. Avoid such activities until you know how the medicine affects you.
Lifestyle Advice
- Practice good sleep hygiene, including maintaining a regular sleep schedule, ensuring a comfortable sleep environment, and avoiding caffeine or heavy meals before bedtime.
- Engage in relaxing activities before sleep, such as reading or a warm bath.
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Global Brand Names
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