Serelam
Generic Name
Alprazolam
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| serelam 05 mg tablet | ৳ 2.01 | ৳ 20.10 |
| serelam 025 mg tablet | ৳ 1.00 | ৳ 10.00 |
Description
Overview of the medicine
Serelam (Alprazolam) is a short-acting benzodiazepine anxiolytic primarily used to treat anxiety disorders, panic disorder, and sometimes anxiety associated with depression.
Uses & Indications
Dosage
Adults
Initial 0.25-0.5 mg orally three times daily, adjusted to maximum 4 mg/day.
Elderly
Initial 0.25 mg orally two to three times daily, adjusted carefully.
Renal_impairment
Use with caution; dose reduction may be necessary.
How to Take
Take orally with or without food. Do not crush or chew if it's an extended-release tablet (though Serelam is standard release).
Mechanism of Action
Enhances the activity of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain, leading to CNS depression.
Pharmacokinetics
Onset
Within 15-30 minutes.
Excretion
Mainly excreted in the urine as metabolites.
Half life
Approximately 11-15 hours (range 6-27 hours).
Absorption
Rapidly absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver primarily by CYP3A4.
Side Effects
Contraindications
- Acute narrow-angle glaucoma
- Known hypersensitivity to benzodiazepines
- Concurrent use with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole)
Drug Interactions
Opioids
Increased risk of respiratory depression, profound sedation, coma, and death.
Alcohol and other CNS depressants
Additive CNS depressant effects.
CYP3A4 inhibitors (e.g., ketoconazole, itraconazole)
Increased alprazolam plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children and dispose of unused medication properly.
Overdose
Symptoms include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Management involves supportive care; flumazenil can be used in severe cases.
Pregnancy & Lactation
Pregnancy Category D. Can cause fetal harm. Avoid during breastfeeding as it is excreted in breast milk and may cause sedation in the infant.
Side Effects
Contraindications
- Acute narrow-angle glaucoma
- Known hypersensitivity to benzodiazepines
- Concurrent use with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole)
Drug Interactions
Opioids
Increased risk of respiratory depression, profound sedation, coma, and death.
Alcohol and other CNS depressants
Additive CNS depressant effects.
CYP3A4 inhibitors (e.g., ketoconazole, itraconazole)
Increased alprazolam plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children and dispose of unused medication properly.
Overdose
Symptoms include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Management involves supportive care; flumazenil can be used in severe cases.
Pregnancy & Lactation
Pregnancy Category D. Can cause fetal harm. Avoid during breastfeeding as it is excreted in breast milk and may cause sedation in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check product label for specific expiry date.
Availability
Available in pharmacies
Approval Status
Approved by health authorities like FDA/DGDA
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have established the efficacy and safety of alprazolam for anxiety and panic disorders, demonstrating its role in symptom reduction.
Lab Monitoring
- Not routinely required. Liver and kidney function tests may be considered in long-term therapy or specific patient populations.
Doctor Notes
- Prescribe for the shortest duration possible to minimize the risk of dependence and withdrawal.
- Assess for risk of abuse before prescribing, especially in patients with a history of substance abuse.
- Warn patients about potential withdrawal symptoms if stopped suddenly and advise gradual tapering.
Patient Guidelines
- Do not stop taking this medication abruptly.
- Avoid alcohol while on this medication.
- This medication can be habit-forming.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for the next dose. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness; avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid activities requiring mental alertness (e.g., driving, operating machinery) until you know how this medicine affects you.
- Limit caffeine intake as it may counteract the effects of alprazolam.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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