Sibalyn
Generic Name
Adapalene
Manufacturer
Acme Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sibalyn 1 cream | ৳ 40.12 | N/A |
Description
Overview of the medicine
Adapalene is a topical retinoid primarily used to treat acne vulgaris. It works by affecting cell growth in hair follicles and reducing inflammation.
Uses & Indications
Dosage
Adults
Apply a thin layer to affected areas once daily in the evening.
Elderly
Same as adults, no specific adjustment needed.
Renal_impairment
No specific adjustment needed for topical use.
How to Take
For topical dermatological use only. Apply a thin film to the entire affected area of the face and other areas of the skin where acne lesions appear, once daily in the evening.
Mechanism of Action
Adapalene modulates cellular differentiation, keratinization, and inflammatory processes. It binds to specific retinoic acid nuclear receptors, but not to the cytosolic receptor protein. It normalizes differentiation of follicular epithelial cells, resulting in decreased microcomedone formation. It also has anti-inflammatory properties.
Pharmacokinetics
Onset
Effects seen within 8-12 weeks.
Excretion
Primarily excreted via the biliary route.
Half life
Systemic half-life not well-established due to minimal absorption.
Absorption
Poorly absorbed through the skin. Systemic exposure is very low.
Metabolism
Metabolized in the liver by O-demethylation, hydroxylation, and conjugation.
Side Effects
Contraindications
- Hypersensitivity to adapalene or any component of the formulation
- Pregnancy
Drug Interactions
Other topical acne treatments
Use with other topical acne treatments (e.g., benzoyl peroxide, salicylic acid) may increase irritation.
Storage
Store below 25°C. Do not freeze. Keep out of reach of children.
Overdose
Excessive application will not produce faster or better results and may result in marked redness, peeling, or discomfort. Management is symptomatic.
Pregnancy & Lactation
Category C in pregnancy. Not recommended during pregnancy. Use with caution during lactation; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to adapalene or any component of the formulation
- Pregnancy
Drug Interactions
Other topical acne treatments
Use with other topical acne treatments (e.g., benzoyl peroxide, salicylic acid) may increase irritation.
Storage
Store below 25°C. Do not freeze. Keep out of reach of children.
Overdose
Excessive application will not produce faster or better results and may result in marked redness, peeling, or discomfort. Management is symptomatic.
Pregnancy & Lactation
Category C in pregnancy. Not recommended during pregnancy. Use with caution during lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Refer to packaging for expiry date.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in treating acne vulgaris.
Lab Monitoring
- Not typically required for topical adapalene.
Doctor Notes
- Advise patients about potential initial worsening and irritation.
- Emphasize consistent use and sun protection.
Patient Guidelines
- Apply only to affected areas.
- Avoid contact with eyes, lips, angles of the nose, and mucous membranes.
- Use sunscreen and protective clothing when exposed to sunlight.
- May cause initial worsening of acne.
- Results may take 8-12 weeks.
Missed Dose Advice
Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not apply extra cream to make up for a missed dose.
Driving Precautions
No known effects on ability to drive or operate machinery.
Lifestyle Advice
- Maintain a good skincare routine.
- Avoid harsh cleansers or abrasive products.
- Stay hydrated.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.