Silatrol
Generic Name
Silatrol 10 mg Tablet
Manufacturer
PharmaGen Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| silatrol 10 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Silatrol 10 mg Tablet is an antidepressant medication belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class, primarily used to treat major depressive disorder, generalized anxiety disorder, and panic disorder.
Uses & Indications
Dosage
Adults
Initial dose 10 mg once daily, may be increased to a maximum of 20 mg daily after 1-2 weeks based on response.
Elderly
Starting dose 5 mg once daily, maximum recommended dose 10 mg daily.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Take Silatrol 10 mg Tablet orally once daily, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Silatrol selectively inhibits the reuptake of serotonin (5-HT) by neurons in the central nervous system. This increases the concentration of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission and alleviating symptoms of depression and anxiety.
Pharmacokinetics
Onset
Initial antidepressant effects may be seen within 1-2 weeks, full therapeutic effects in 4-6 weeks.
Excretion
Excreted mainly through urine and feces as metabolites.
Half life
Approximately 20-24 hours.
Absorption
Well absorbed orally, with peak plasma concentrations reached within 4-6 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Silatrol or any excipients
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI
- Concomitant use with pimozide
Drug Interactions
MAOIs
Risk of serotonin syndrome. Avoid concomitant use.
NSAIDs
May increase risk of gastrointestinal bleeding.
Warfarin
May increase the risk of bleeding. Monitor INR.
Other serotonergic drugs (e.g., triptans, tramadol)
Increased risk of serotonin syndrome.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, tremor, somnolence, nausea, vomiting, tachycardia, and rarely, seizures or coma. Treatment is symptomatic and supportive. Maintain an open airway, monitor cardiac rhythm and vital signs. Gastric lavage and activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Silatrol is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to Silatrol or any excipients
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI
- Concomitant use with pimozide
Drug Interactions
MAOIs
Risk of serotonin syndrome. Avoid concomitant use.
NSAIDs
May increase risk of gastrointestinal bleeding.
Warfarin
May increase the risk of bleeding. Monitor INR.
Other serotonergic drugs (e.g., triptans, tramadol)
Increased risk of serotonin syndrome.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, tremor, somnolence, nausea, vomiting, tachycardia, and rarely, seizures or coma. Treatment is symptomatic and supportive. Maintain an open airway, monitor cardiac rhythm and vital signs. Gastric lavage and activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Silatrol is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Pending
Clinical Trials
Silatrol has undergone extensive Phase I, II, and III clinical trials demonstrating its efficacy and safety profile for major depressive disorder and anxiety disorders.
Lab Monitoring
- No routine laboratory monitoring is typically required, but liver function tests may be considered in patients with hepatic impairment. Monitor serum sodium levels in elderly or volume-depleted patients.
Doctor Notes
- Emphasize the importance of patient adherence to the prescribed dosage and duration of treatment.
- Advise gradual tapering when discontinuing to minimize withdrawal symptoms.
- Monitor for signs of suicidality, especially at the initiation of therapy or during dose adjustments.
Patient Guidelines
- Do not stop taking Silatrol suddenly, as it may lead to withdrawal symptoms. Consult your doctor for a gradual reduction plan.
- Avoid alcohol while on this medication.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Silatrol may cause dizziness, drowsiness, or impaired concentration. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Engage in regular physical activity.
- Practice stress-reduction techniques like meditation or yoga.
- Ensure adequate sleep.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.